The accurate transition from G1 phase of the cell cycle to S phase is crucial for the control of
eukaryotic cell proliferation, and its misregulation promotes oncogenesis. During G1 phase …

Much has been written about the functions of the E2F transcription factor and the product of
the retinoblastoma tumor suppressor gene (pRB). These proteins have been described in …

In mammalian cells, the decision to proliferate is thought to be irreversibly made at the
restriction point of the cell cycle,, when mitogen signalling engages a positive feedback loop …

▪ Abstract The eucaryotic cell cycle is regulated by the periodic synthesis and destruction of
cyclins that associate with and activate cyclin-dependent kinases. Cyclin-dependent kinase …

Approximately 200 human papillomaviruses (HPVs) infect human epithelial cells, of which
the alpha and beta types have been the most extensively studied. Alpha HPV types mainly …

Although a number of transfection experiments have suggested potential targets for the
action of the E2F1 transcription factor, as is the case for many transcriptional regulatory …

A key event in the regulation of eukaryotic gene expression is the posttranslational
modification of nucleosomal histones, which converts regions of chromosomes into …

E2F transcription activity is composed of a family of heterodimers encoded by distinct genes.
Through the overproduction of each of the five known E2F proteins in mammalian cells, we …

Most cervical carcinomas express high-risk human papillomaviruses (HPVs) E6 and E7
proteins, which neutralize cellular tumor suppressor function. To determine the …

The retinoblastoma (RB) family of proteins are found in organisms as distantly related as
humans, plants, and insects. These proteins play a key role in regulating advancement of …