The sequence of chromosome 21 was a turning point for the understanding of Down
syndrome. Comparative genomics is beginning to identify the functional components of the …

Down syndrome, the most common genetic cause of intellectual disabilities, was first
described in 1866, during an era of great change in our understanding of genetics and …

Ascertaining when and where genes are expressed is of crucial importance to
understanding or predicting the physiological role of genes and proteins and how they …

This advanced textbook is tailored for an introductory course in Systems Biology and is well-
suited for biologists as well as engineers and computer scientists. It comes with student …

Background The regulatory mechanisms underlying tissue specificity are a crucial part of the
development and maintenance of multicellular organisms. A genome-wide analysis of …

The science of genetics is undergoing a paradigm shift. Recent discoveries, including the
activity of retrotransposons, the extent of copy number variations, somatic and chromosomal …

Human trisomy 21, which results in Down syndrome (DS), is one of the most complicated
congenital genetic anomalies compatible with life, yet little is known about the molecular …

Transient megakaryoblastic leukaemia is found in 10% of newborns with Down syndrome,
characterized by constitutional trisomy 21. Although in most cases the leukaemic cells …

With an incidence of approximately 1 in 700 live births, Down syndrome (DS) remains the
most common genetic cause of mental retardation. The phenotype is assumed to be due to …

Doxorubicin is a highly effective antineoplastic agent, but it can produce the serious side
effects of acute cardiac injury and chronic congestive heart failure. Carbonyl reductase …