The ribosome is a multi-unit complex that translates mRNA into protein. Ribosome
biogenesis is the process that generates ribosomes and plays an essential role in cell …

BACKGROUND Ribosomopathies are a heterogeneous group of human disorders that are
in some cases known, and in other cases suspected, to result from ribosome dysfunction …

Although ribosomal proteins are known for playing an essential role in ribosome assembly
and protein translation, their ribosome-independent functions have also been greatly …

Advances in sequencing and high-throughput techniques have provided an unprecedented
opportunity to interrogate human diseases on a genome-wide scale. The list of disease …

Cells typically respond quickly to stress, altering their metabolism to compensate. In
mammalian cells, stress signaling usually leads to either cell-cycle arrest or apoptosis …

Regulation of mRNA translation offers the opportunity to diversify the expression and
abundance of proteins made from individual gene products in cells, tissues and organisms …

The biosynthesis of ribosomes is a complex process that requires the coordinated action of
many factors and a huge energy investment from the cell. Ribosomes are essential for …

Cardiovascular disease (CVD) remains the leading cause of mortality globally, so further
investigation is required to identify its underlying mechanisms and potential targets for its …

Ribosomopathies compose a collection of disorders in which genetic abnormalities cause
impaired ribosome biogenesis and function, resulting in specific clinical phenotypes …

Although metabolic alterations have been observed in cancer for almost a century, only
recently have the mechanisms underlying these changes been identified and the …