Bone-tissue defects affect millions of people worldwide. Despite being common treatment
approaches, autologous and allogeneic bone grafting have not achieved the ideal …

To induce bone regeneration there is a complex cascade of growth factors. Growth factors
such as recombinant BMP-2, BMP-7, and PDGF are FDA-approved therapies in bone …

Osteoporosis is a systemic metabolic bone disease with characteristics of bone loss and
microstructural degeneration. The personal and societal costs of osteoporosis are …

Skeletal disorders are among the leading debilitating factors affecting millions of people
worldwide. The use of stem cells for tissue repair has raised many promises in various …

Diabetic skin ulcer is one of the severe complications of diabetes mellitus, which has a high
incidence and may cause death or disability. Platelet-rich plasma (PRP) is widely used in …

Bone fractures and segmental bone defects are a significant source of patient morbidity and
place a staggering economic burden on the healthcare system. The annual cost of treating …

Vascular endothelial growth factor-A (VEGF) is one of the most important growth factors for
regulation of vascular development and angiogenesis. Since bone is a highly vascularized …

Osteoblast-derived VEGF is important for bone development and postnatal bone
homeostasis. Previous studies have demonstrated that VEGF affects bone repair and …

Purpose. Guided tissue reconstruction can be performed to restore the supporting structure
of a previously lost tooth, which, in addition to maintaining beauty, preserves the function of …

Osteogenesis during bone modeling and remodeling is coupled with angiogenesis. A recent
study showed that a specific vessel subtype, strongly positive for CD31 and endomucin …