A comprehensive account on recent progress in pharmacological activities of benzimidazole derivatives

SR Brishty, MJ Hossain, MU Khandaker… - Frontiers in …, 2021 - frontiersin.org
Nowadays, nitrogenous heterocyclic molecules have attracted a great deal of interest
among medicinal chemists. Among these potential heterocyclic drugs, benzimidazole …

[HTML][HTML] Benzimidazole and its derivatives as cancer therapeutics: The potential role from traditional to precision medicine

YT Lee, YJ Tan, CE Oon - Acta Pharmaceutica Sinica B, 2023 - Elsevier
Cancer is the second leading cause of mortality globally which remains a continuing threat
to human health today. Drug insensitivity and resistance are critical hurdles in cancer …

Heterocyclic compounds: pharmacology of pyrazole analogs from rational structural considerations

RF Costa, LC Turones, KVN Cavalcante… - Frontiers in …, 2021 - frontiersin.org
Low quality of life and life-threatening conditions often demand pharmacological screening
of lead compounds. A spectrum of pharmacological activities has been attributed to pyrazole …

Synthesis of antimicrobial benzimidazole–pyrazole compounds and their biological activities

M Marinescu - Antibiotics, 2021 - mdpi.com
The synthesis of new compounds with antimicrobial and antiviral properties is a central
objective today in the context of the COVID-19 pandemic. Benzimidazole and pyrazole …

[HTML][HTML] Benzimidazole and its derivatives: Recent Advances (2020–2022)

O Ebenezer, F Oyetunde-Joshua, OD Omotoso… - Results in …, 2023 - Elsevier
Benzimidazoles are fused heterocyclic ring systems containing two nitrogen atoms. They
have vital therapeutic significance in drug discovery. Many clinically approved drugs have …

Recent advancements on benzimidazole: A versatile scaffold in medicinal chemistry

ZMM Alzhrani, MM Alam… - Mini Reviews in Medicinal …, 2022 - ingentaconnect.com
Benzimidazole is a nitrogen-containing fused heterocycle which has been extensively
explored in medicinal chemistry. Benzimidizole nucleus has been found to possess various …

Novel Isoxazole Derivative Attenuates Ethanol-Induced Gastric Mucosal Injury through Inhibition of H+/K+-ATPase Pump, Oxidative Stress and Inflammatory …

S Razzaq, AM Minhas, NG Qazi, H Nadeem, A Khan… - Molecules, 2022 - mdpi.com
Isoxazole derivatives are significant enough due to their wide range of pharmacological and
therapeutic activities. The purpose of the current study is to use computational, in vitro, in …

The medicinal panorama of benzimidazoles and their scaffolds as anticancer and antithrombotic agents: A review

PKB Chalkappa, S Aralihalli, M Sudileti… - Archiv der …, 2023 - Wiley Online Library
Nitrogen‐containing heterocyclic scaffolds have become a prospective pharmacophore with
therapeutic importance due to their biological similarities with natural and synthetic drugs …

Pharmacological Basis of Rumex hastatus D. Don in Gastrointestinal Diseases with Focusing Effects on H+/K+-ATPase, Calcium Channels Inhibition and PDE …

NG Qazi, A Khan, SW Abbasi, FA Shah, F Rasheed… - Molecules, 2022 - mdpi.com
This present study aimed to delineate Rumex hastatus D. Don crude extract (Rh. Cr), n-
Hexane, ethyl acetate, aqueous fractions (Rh. n-Hex, Rh. ETAC, Rh. Aq) and rutin for …

Recent Advancements in Strategies for the Synthesis of Imidazoles, Thiazoles, Oxazoles, and Benzimidazoles

K Kant, CK Patel, S Banerjee, P Naik, AK Atta… - …, 2023 - Wiley Online Library
Nitrogen‐containing heterocycles such as imidazoles, thiazoles, and oxazoles play a
significant role in the fields of biological and pharmaceutical chemistry. These compounds …