Autism spectrum disorder (ASD) encompasses a group of multifactorial neurodevelopmental
disorders characterized by impaired social communication, social interaction and repetitive …

Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlapping behavioral phenotypes, which suggests …

Synapses are essential components of neurons and allow information to travel coordinately
throughout the nervous system to adjust behavior to environmental stimuli and to control …

Hyperconnectivity of neuronal circuits due to increased synaptic protein synthesis is thought
to cause autism spectrum disorders (ASDs). The mammalian target of rapamycin (mTOR) is …

Synapse organizing proteins are multifaceted molecules that coordinate the complex
processes of brain development and plasticity at the level of individual synapses. Their …

Neuroligins (NLs) are a family of neural cell-adhesion molecules that are involved in
excitatory/inhibitory synapse specification. Multiple members of the NL family (including …

Synapses are essential for transmitting, processing, and storing information, all of which
decline in aging and Alzheimer's disease (AD). Because synapse loss only partially …

Chemical synapses are asymmetric intercellular junctions that mediate synaptic
transmission. Synaptic junctions are organized by trans-synaptic cell adhesion molecules …

Adhesive contact between pre-and postsynaptic neurons initiates synapse formation during
brain development and provides a natural means of transsynaptic signaling. Numerous …

Neurexins (NXs) and neuroligins (NLs) are transsynaptically interacting cell adhesion
proteins that play a key role in the formation, maturation, activity-dependent validation, and …