Alzheimer's disease (AD) was first described a little more than 100 years ago. It is the most
common cause of dementia with an estimated prevalence of 30 million people worldwide, a …

Family history is the second strongest risk factor for Alzheimer disease (AD) following
advanced age. Twin and family studies indicate that genetic factors are estimated to play a …

Innate immunity is associated with Alzheimer's disease, but the influence of immune
activation on the production of amyloid-β is unknown,. Here we identify interferon-induced …

Development of γ-secretase inhibitors (GSIs) and modulators (GSMs) represents an
attractive therapeutic opportunity for Alzheimer's disease (AD) and cancers. However, how …

Thiazole, a unique heterocycle containing sulphur and nitrogen atoms, occupies an
important place in medicinal chemistry. It is an essential core scaffold present in many …

Alzheimer disease (AD) represents an oncoming epidemic that without an effective
treatment promises to exact extraordinary financial and emotional burdens. Studies of …

The Alzheimer's disease (AD)-associated amyloid-β protein precursor (AβPP) is cleaved by
α-, β-, and presenilin (PS)/γ-secretases through sequential regulated proteolysis. These …

Abstract γ-Secretase is a fascinating, multi-subunit, intramembrane cleaving protease that is
now being considered as a therapeutic target for a number of diseases. Potent, orally …

Near-infrared fluorescence (NIRF) molecular imaging has been widely applied to monitoring
therapy of cancer and other diseases in preclinical studies; however, this technology has not …

Alzheimers disease (AD) is a devastating neurodegenerative disease of the elderly
population. Genetic evidence strongly suggests that aberrant generation and/or clearance of …