Alzheimer's disease: the challenge of the second century
DM Holtzman, JC Morris, AM Goate - Science translational medicine, 2011 - science.org
Alzheimer's disease (AD) was first described a little more than 100 years ago. It is the most
common cause of dementia with an estimated prevalence of 30 million people worldwide, a …
common cause of dementia with an estimated prevalence of 30 million people worldwide, a …
The genetics of Alzheimer disease
RE Tanzi - Cold Spring Harbor perspectives in …, 2012 - perspectivesinmedicine.cshlp.org
Family history is the second strongest risk factor for Alzheimer disease (AD) following
advanced age. Twin and family studies indicate that genetic factors are estimated to play a …
advanced age. Twin and family studies indicate that genetic factors are estimated to play a …
The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease
Innate immunity is associated with Alzheimer's disease, but the influence of immune
activation on the production of amyloid-β is unknown,. Here we identify interferon-induced …
activation on the production of amyloid-β is unknown,. Here we identify interferon-induced …
Structural basis of γ-secretase inhibition and modulation by small molecule drugs
Development of γ-secretase inhibitors (GSIs) and modulators (GSMs) represents an
attractive therapeutic opportunity for Alzheimer's disease (AD) and cancers. However, how …
attractive therapeutic opportunity for Alzheimer's disease (AD) and cancers. However, how …
Thiazole: A review on chemistry, synthesis and therapeutic importance of its derivatives
MT Chhabria, S Patel, P Modi… - Current topics in …, 2016 - ingentaconnect.com
Thiazole, a unique heterocycle containing sulphur and nitrogen atoms, occupies an
important place in medicinal chemistry. It is an essential core scaffold present in many …
important place in medicinal chemistry. It is an essential core scaffold present in many …
Exploring the pathogenesis of Alzheimer disease in basal forebrain cholinergic neurons: converging insights from alternative hypotheses
XQ Chen, WC Mobley - Frontiers in neuroscience, 2019 - frontiersin.org
Alzheimer disease (AD) represents an oncoming epidemic that without an effective
treatment promises to exact extraordinary financial and emotional burdens. Studies of …
treatment promises to exact extraordinary financial and emotional burdens. Studies of …
The many substrates of presenilin/γ-secretase
A Haapasalo, DM Kovacs - Journal of Alzheimer's disease, 2011 - content.iospress.com
The Alzheimer's disease (AD)-associated amyloid-β protein precursor (AβPP) is cleaved by
α-, β-, and presenilin (PS)/γ-secretases through sequential regulated proteolysis. These …
α-, β-, and presenilin (PS)/γ-secretases through sequential regulated proteolysis. These …
[HTML][HTML] γ-Secretase inhibitors and modulators
TE Golde, EH Koo, KM Felsenstein, BA Osborne… - … et Biophysica Acta (BBA …, 2013 - Elsevier
Abstract γ-Secretase is a fascinating, multi-subunit, intramembrane cleaving protease that is
now being considered as a therapeutic target for a number of diseases. Potent, orally …
now being considered as a therapeutic target for a number of diseases. Potent, orally …
Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer's disease
Near-infrared fluorescence (NIRF) molecular imaging has been widely applied to monitoring
therapy of cancer and other diseases in preclinical studies; however, this technology has not …
therapy of cancer and other diseases in preclinical studies; however, this technology has not …
[HTML][HTML] Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase
H Steiner, A Fukumori, S Tagami, M Okochi - Cell Stress, 2018 - ncbi.nlm.nih.gov
Alzheimers disease (AD) is a devastating neurodegenerative disease of the elderly
population. Genetic evidence strongly suggests that aberrant generation and/or clearance of …
population. Genetic evidence strongly suggests that aberrant generation and/or clearance of …