Apoptosis is a form of programmed cell death that is regulated by the balance between
prosurvival and proapoptotic BCL-2 protein family members. Evasion of apoptosis is a …

The advent of cancer therapeutics brought a paradigm shift from conventional therapy to
precision medicine. The new therapeutic modalities accomplished through the properties of …

Excessive STAT3 signalling via gp130, the shared receptor subunit for IL-6 and IL-11,
contributes to disease progression and poor survival outcomes in patients with colorectal …

The deregulation of apoptosis is a key contributor to tumourigenesis as it can lead to the
unwanted survival of rogue cells. Drugs known as the BH3-mimetics targeting the pro …

Abstract Metastatic BRAF V600E colorectal cancer (CRC) carries an extremely poor
prognosis and is in urgent need of effective new treatments. While the BRAFV600E inhibitor …

Thiadiazole derivatives have garnered significant attention in the field of medicinal chemistry
due to their diverse pharmacological activities, including anticancer properties. This article …

Osteosarcoma is the most common form of primary bone cancer, which primarily afflicts
children and adolescents. Chemotherapy, consisting of doxorubicin, cisplatin and …

Adenomatous polyposis coli (APC) truncations occur in many colorectal cancers and are
often associated with immune infiltration. The aim of this study was to determine whether a …

Recent advances in melanoma therapy have significantly improved the prognosis of
metastasized melanoma. However, large therapeutic gaps remain that need to be closed by …

In this study, we synthesized and characterized a zwitterionic polymer based on the 4-
vinylpyridine monomer (4-VP) and used it as a practical drug carrier for 5-fluorouracil (5-FU) …