Pseudomonas aeruginosa adaptation and evolution in patients with cystic fibrosis

E Rossi, R La Rosa, JA Bartell, RL Marvig… - Nature Reviews …, 2021 - nature.com
Intense genome sequencing of Pseudomonas aeruginosa isolates from cystic fibrosis (CF)
airways has shown inefficient eradication of the infecting bacteria, as well as previously …

Industrial biotechnology of Pseudomonas putida: advances and prospects

A Weimer, M Kohlstedt, DC Volke, PI Nikel… - Applied Microbiology …, 2020 - Springer
Pseudomonas putida is a Gram-negative, rod-shaped bacterium that can be encountered in
diverse ecological habitats. This ubiquity is traced to its remarkably versatile metabolism …

[HTML][HTML] Unraveling antimicrobial resistance using metabolomics

M Kok, L Maton, M van der Peet, T Hankemeier… - Drug Discovery …, 2022 - Elsevier
The emergence of antimicrobial resistance (AMR) in bacterial pathogens represents a
global health threat. The metabolic state of bacteria is associated with a range of genetic …

Oxidative Stress Response in Pseudomonas aeruginosa

WS da Cruz Nizer, V Inkovskiy, Z Versey, N Strempel… - Pathogens, 2021 - mdpi.com
Pseudomonas aeruginosa is a Gram-negative environmental and human opportunistic
pathogen highly adapted to many different environmental conditions. It can cause a wide …

Impact of artificial sputum medium formulation on Pseudomonas aeruginosa secondary metabolite production

RL Neve, BD Carrillo, VV Phelan - Journal of bacteriology, 2021 - Am Soc Microbiol
In vitro culture media are being developed to understand how host site-specific nutrient
profiles influence microbial pathogenicity and ecology. To mimic the cystic fibrosis (CF) lung …

Bacterial acetate metabolism and its influence on human epithelia

J Hosmer, AG McEwan, U Kappler - Emerging topics in life …, 2023 - portlandpress.com
Short-chain fatty acids are known modulators of host–microbe interactions and can affect
human health, inflammation, and outcomes of microbial infections. Acetate is the most …

Exogenous D-ribose promotes gentamicin treatment of several drug-resistant Salmonella

Y Zhou, Y Yong, C Zhu, H Yang, B Fang - Frontiers in microbiology, 2022 - frontiersin.org
The metabolic microenvironment of bacteria impacts drug efficacy. However, the metabolic
mechanisms of drug-resistant Salmonella spp. remain largely unknown. This study …

Microbial upgrading of acetate into value-added products—examining microbial diversity, bioenergetic constraints and metabolic engineering approaches

R Kutscha, S Pflügl - International journal of molecular sciences, 2020 - mdpi.com
Ecological concerns have recently led to the increasing trend to upgrade carbon contained
in waste streams into valuable chemicals. One of these components is acetate. Its microbial …

Current knowledge and future directions in developing strategies to combat Pseudomonas aeruginosa infection

SK Dolan - Journal of molecular biology, 2020 - Elsevier
In the face of growing antimicrobial resistance, there is an urgent need for the development
of effective strategies to target Pseudomonas aeruginosa. This metabolically versatile …

Leveraging substrate flexibility and product selectivity of acetogens in two‐stage systems for chemical production

L Ricci, A Seifert, S Bernacchi, D Fino… - Microbial …, 2023 - Wiley Online Library
Carbon dioxide (CO2) stands out as sustainable feedstock for developing a circular carbon
economy whose energy supply could be obtained by boosting the production of clean …