Endothelial to mesenchymal transition (EndMT) is a complex biological process that gives
rise to cells with multipotent potential. EndMT is essential for the formation of the …

During metastasis, cancer cells disseminate to other parts of the body by entering the
bloodstream in a process that is called intravasation. They then extravasate at metastatic …

While most cancer nanomedicine is designed to eliminate cancer, the nanomaterial per se
can lead to the formation of micrometre-sized gaps in the blood vessel endothelial walls …

Tumours require a vascular supply to grow and can achieve this via the expression of pro-
angiogenic growth factors, including members of the vascular endothelial growth factor …

Aberrant neovascularization contributes to diseases such as cancer, blindness and
atherosclerosis, and is the consequence of inappropriate angiogenic signalling. Although …

The primary hemostatic function of platelets has been recognized for more than a century,
but increasing experimental and clinical evidences suggest that platelets are also important …

Purpose: Cancer-associated fibroblasts (CAF) are a major component of the colorectal
cancer tumor microenvironment. CAFs play an important role in tumor progression and …

Angiogenesis is a critical process required for tumor progression. Newly formed blood
vessels provide nutrition and oxygen to the tumor contributing to its growth and …

The concept of antiangiogenic therapy in cancer treatment has led to the approval of
different agents, most of them targeting the well known vascular endothelial growth factor …

Cancer is one of the most important causes of morbidity and mortality worldwide. Tumor
cells grow in a complex microenvironment constituted of immune, stromal, and vascular cells …