The gastrointestinal tract is a highly proliferative and regenerative tissue. The intestine also
harbors a large and diverse microbial population collectively called the gut microbiome …

The culture of Chinese Hamster Ovary (CHO) cells for modern industrial applications, such
as expression of recombinant proteins, requires media that support growth and production …

For over three decades, Chinese hamster ovary (CHO) cells have been the chosen
expression platform for the production of therapeutic proteins with complex post …

To harness the full potential of human pluripotent stem cells (hPSCs) we combined
instrumented stirred tank bioreactor (STBR) technology with the power of in silico process …

We applied a parallel labeling strategy using two isotopic tracers,[1, 2-13C] glucose and [U-
13C] glutamine, to determine metabolic fluxes in Chinese hamster ovary (CHO) cells. CHO …

Large-scale fed-batch cell culture processes of CHO cells are the standard platform for the
clinical and commercial production of monoclonal antibodies. Lactate is one of the major by …

The emergence of the biopharmaceutical industry represented a major revolution for
modern medicine, through the development of recombinant therapeutic proteins that brought …

Chinese hamster ovary (CHO) cells in culture are known to consume large amounts of
nutrients and divert most of them toward byproducts, some of which, including lactate and …

An efficient rapid protein expression system is crucial to support early drug development.
Transient gene expression is an effective route, and to facilitate the use of the same host …

To characterize a glutamine synthetase (GS)-based selection system, monoclonal antibody
(mAb) producing recombinant CHO cell clones were generated by a single round of …