Collagen is the oldest and most abundant extracellular matrix protein that has found many
applications in food, cosmetic, pharmaceutical, and biomedical industries. First, an overview …

Analysis of the human genome reveals that approximately a third of all open reading frames
code for proteins that enter the endoplasmic reticulum (ER), demonstrating the importance of …

Hsp47, a collagen-specific molecular chaperone that localizes in the endoplasmic reticulum
(ER), is indispensable for molecular maturation of collagen. Hsp47, which is encoded by the …

The collagen superfamily of proteins plays a dominant role in maintaining the integrity of
various tissues and also has a number of other important functions. The superfamily now …

The enzymes of the protein disulfide isomerase (PDI) family are thiol–disulfide
oxidoreductases of the endoplasmic reticulum (ER). They contain a CXXC active-site …

Heat shock protein 47 (Hsp47) is an endoplasmic reticulum (ER)-resident molecular
chaperone essential for correct folding of procollagen in mammalian cells. In this Review …

In this chapter, we discuss the current understanding of the family of matrix macromolecules
that are classified as collagens. Reference is made to reviews and recent papers to provide …

The major clinical feature that defines osteogenesis imperfecta (OI) is bone fragility. We
begin the chapter with a discussion of the history, prevalence, and classification of OI. After a …

ERp57 is a lumenal protein of the endoplasmic reticulum (ER) and a member of the protein
disulfide isomerase (PDI) family. In contrast to archetypal PDI, ERp57 interacts specifically …

Extracellular matrix (ECM) proteins create structural frameworks in tissues such as bone,
skin, tendon and cartilage etc. These connective tissues play important roles in the …