Fungal morphology: a challenge in bioprocess engineering industries for product development

HA El Enshasy - Current Opinion in Chemical Engineering, 2022 - Elsevier
Fungal biofactories are well established in bioprocess industries. They have been used for
the production of essential biomolecules in chemical, food, and pharmaceutical industries …

Something old, something new: challenges and developments in Aspergillus niger biotechnology

TC Cairns, L Barthel, V Meyer - Essays in Biochemistry, 2021 - portlandpress.com
The filamentous ascomycete fungus Aspergillus niger is a prolific secretor of organic acids,
proteins, enzymes and secondary metabolites. Throughout the last century, biotechnologists …

Understanding and controlling filamentous growth of fungal cell factories: novel tools and opportunities for targeted morphology engineering

V Meyer, T Cairns, L Barthel, R King, P Kunz… - Fungal Biology and …, 2021 - Springer
Filamentous fungal cell factories are efficient producers of platform chemicals, proteins,
enzymes and natural products. Stirred-tank bioreactors up to a scale of several hundred m³ …

Cellular organization in lab-evolved and extant multicellular species obeys a maximum entropy law

TC Day, SS Höhn, SA Zamani-Dahaj, D Yanni… - Elife, 2022 - elifesciences.org
The prevalence of multicellular organisms is due in part to their ability to form complex
structures. How cells pack in these structures is a fundamental biophysical issue, underlying …

Synchrotron radiation‐based microcomputed tomography for three‐dimensional growth analysis of Aspergillus niger pellets

H Müller, C Deffur, S Schmideder… - Biotechnology and …, 2023 - Wiley Online Library
Filamentous fungi produce a wide range of relevant biotechnological compounds. The close
relationship between fungal morphology and productivity has led to a variety of analytical …

From spores to fungal pellets: A new high‐throughput image analysis highlights the structural development of Aspergillus niger

H Müller, L Barthel, S Schmideder… - Biotechnology and …, 2022 - Wiley Online Library
Many filamentous fungi are exploited as cell factories in biotechnology. Cultivated under
industrially relevant submerged conditions, filamentous fungi can adopt different …

Low pressure gas transfer in fibrous media with progressive infiltration: correlation between different transfer modes

C Charles, C Descamps, GL Vignoles - … Journal of Heat and Mass Transfer, 2022 - Elsevier
Permeation of gases in fibrous preforms of C/C composites has been studied with various
degrees of infiltration, between 60% and 12% pore volume fraction, both experimentally with …

3D imaging and analysis to unveil the impact of microparticles on the pellet morphology of filamentous fungi

A Dinius, H Müller, D Kellhammer… - Biotechnology and …, 2024 - Wiley Online Library
Controlling the morphology of filamentous fungi is crucial to improve the performance of
fungal bioprocesses. Microparticle‐enhanced cultivation (MPEC) increases productivity …

Varied solutions to multicellularity: The biophysical and evolutionary consequences of diverse intercellular bonds

TC Day, P Márquez-Zacarías, P Bravo, AR Pokhrel… - Biophysics …, 2022 - pubs.aip.org
The diversity of multicellular organisms is, in large part, due to the fact that multicellularity
has independently evolved many times. Nonetheless, multicellular organisms all share a …

Regression modelling of conditional morphogene expression links and quantifies the impact of growth rate, fitness and macromorphology with protein secretion in …

TC Cairns, T de Kanter, XZ Zheng, P Zheng… - … for Biofuels and …, 2023 - Springer
Background Filamentous fungi are used as industrial cell factories to produce a diverse
portfolio of proteins, organic acids, and secondary metabolites in submerged fermentation …