Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Calcium ions function as a key second messenger ion in eukaryotes. Spatially and
temporally defined cytoplasmic Ca2+ signals are shaped through the concerted activity of …

The transient receptor potential ion channel TRPA1 is expressed by primary afferent nerve
fibres, in which it functions as a low-threshold sensor for structurally diverse electrophilic …

Plasma membrane-associated and intracellular proteins and protein complexes play a
pivotal role in pathogen recognition and disease resistance signaling in plants and animals …

Despite the development of effective therapies, a substantial proportion of asthmatics
continue to have uncontrolled symptoms, airflow limitation, and exacerbations. Transient …

The transient receptor potential melastatin 8 (TRPM8) channel is the primary molecular
transducer responsible for the cool sensation elicited by menthol and cold in mammals …

Transient receptor potential (TRP) ion channels are sophisticated signaling machines that
detect a wide variety of environmental and physiological signals. Every cell in the body …

The perception of nociceptive signals, which are translated into pain, plays a fundamental
role in the survival of organisms. Because pain is linked to a negative sensation, animals …

Chronic pain treatment remains a sore challenge, and in our aging society, the number of
patients reporting inadequate pain relief continues to grow. Current treatment options all …

Transient receptor potential (TRP) ion channels are evolutionarily ancient sensory proteins
that detect and integrate a wide range of physical and chemical stimuli. TRP channels are …