Marine microbial bioprospecting: Exploitation of marine biodiversity towards biotechnological applications—a review

H Hosseini, HM Al‐Jabri, NR Moheimani… - Journal of Basic …, 2022 - Wiley Online Library
The increase in the human population causes an increase in the demand for nutritional
supplies and energy resources. Thus, the novel, natural, and renewable resources became …

[HTML][HTML] A guide to the use of bioassays in exploration of natural resources

J Sabotič, E Bayram, D Ezra, SP Gaudêncio… - Biotechnology …, 2024 - Elsevier
Bioassays are the main tool to decipher bioactivities from natural resources thus their
selection and quality are critical for optimal bioprospecting. They are used both in the early …

Pharmacoinformatics and preclinical studies of nsc765690 and nsc765599, potential stat3/cdk2/4/6 inhibitors with antitumor activities against nci60 human tumor cell …

B Lawal, YL Liu, N Mokgautsi, H Khedkar, MR Sumitra… - Biomedicines, 2021 - mdpi.com
Signal transducer and activator of transcription 3 (STAT3) is a transcriptional regulator of a
number of biological processes including cell differentiation, proliferation, survival, and …

Role of bioinformatics and pharmacogenomics in drug discovery and development process

P Katara - Network Modeling Analysis in Health Informatics and …, 2013 - Springer
Drug discovery and development is a complex, high risk, time consuming and potentially
highly rewarding process. Pharmaceutical companies literally burn millions of dollar per …

[HTML][HTML] Inhibition of COVID-19 RNA-dependent RNA polymerase by natural bioactive compounds: Molecular docking analysis

NMA El-Aziz, MG Shehata, OME Awad, SA El-Sohaimy - 2020 - europepmc.org
Till now there is no approved treatment for COVID-19. Phenolic compounds are known to
have antiviral activity against many viruses such as HCV and HIV, through their phenol rings …

Computationally approached inhibition potential of Tinospora cordifolia towards COVID-19 targets

S Jena, P Munusami, B Mm, K Chanda - Virusdisease, 2021 - Springer
The recent emergence of novel coronavirus (SARS-CoV-2) has been a major threat to
human society, as the challenge of finding suitable drug or vaccine is not met till date. With …

Antioxidant and anti-acetylcholinesterase potential of artichoke phenolic compounds

NM Abd El-Aziz, OME Awad, MG Shehata… - Food Bioscience, 2021 - Elsevier
The present study focused on the biochemical evaluation of artichoke extract, furthermore, in
vitro and in silico evaluation its potential for inhibition of acetylcholinesterase activity. The …

Bioinformatics for marine products: An overview of resources, bottlenecks, and perspectives

L Ambrosino, M Tangherlini, C Colantuono, A Esposito… - Marine drugs, 2019 - mdpi.com
The sea represents a major source of biodiversity. It exhibits many different ecosystems in a
huge variety of environmental conditions where marine organisms have evolved with …

[PDF][PDF] Potential COVID-19 drug from natural phenolic compounds through in silico virtual screening approach

T Rathinavel, B Meganathan… - Biointerface Res Appl …, 2020 - researchgate.net
SARS CoV-2 causes a world pandemic disease called COVID-19. In the present study,
natural phenol and flavonoid compounds from food sources are used to search for effective …

Quality by design (QbD) approach of pharmacogenomics in drug designing and formulation development for optimization of drug delivery systems

S Gupta, V Jhawat - Journal of Controlled Release, 2017 - Elsevier
Conventional approaches of drug discovery are very complex, costly and time consuming.
But after the completion of human genome project, applications of pharmacogenomics in …