Aberrant energy metabolism in Alzheimer's disease

L Yu, J Jin, Y Xu, X Zhu - Journal of translational internal medicine, 2022 - degruyter.com
To maintain energy supply to the brain, a direct energy source called adenosine
triphosphate (ATP) is produced by oxidative phosphorylation and aerobic glycolysis of …

The Role of Cardiolipin in Mitochondrial Function and Neurodegenerative Diseases

JM Fuentes, P Morcillo - Cells, 2024 - mdpi.com
Cardiolipin (CL) is a mitochondria-exclusive phospholipid synthesized in the inner
mitochondrial membrane. CL plays a key role in mitochondrial membranes, impacting a …

[HTML][HTML] Cardiolipin externalization mediates prion protein (PrP) peptide 106–126-associated mitophagy and mitochondrial dysfunction

D Yang, J Li, Z Li, M Zhao, D Wang, Z Sun… - Frontiers in Molecular …, 2023 - frontiersin.org
Proper mitochondrial performance is imperative for the maintenance of normal neuronal
function to prevent the development of neurodegenerative diseases. Persistent …

Vitamin B12 attenuates changes in phospholipid levels related to oxidative stress in SH-SY5Y cells

EL Theiss, LV Griebsch, AA Lauer, D Janitschke… - Cells, 2022 - mdpi.com
Oxidative stress is closely linked to Alzheimer's disease (AD), and is detected peripherally
as well as in AD-vulnerable brain regions. Oxidative stress results from an imbalance …

[HTML][HTML] In vitro Neuroprotective Potential and Lipidomics Study of Olive Leaves Extracts Enriched in Triterpenoids

R Gallego, ZJ Suárez-Montenegro, E Ibáñez… - Frontiers in …, 2021 - frontiersin.org
Alzheimer's Disease (AD) is the most common form of dementia that is associated with
extracellular amyloid beta (Aβ) plaque formation. Genetic, environmental, and nutrition …

An integrative analysis of lipidomics and transcriptomics in various mouse brain regions in response to real-ambient PM2. 5 exposure

S Qin, H Zeng, Q Wu, Q Li, M Zeeshan, L Ye… - Science of The Total …, 2023 - Elsevier
Exposure to Fine particulate matter (PM 2.5) has been associated with various neurological
disorders. However, the underlying mechanisms of PM 2.5-induced adverse effects on the …

Development and validation of a plasmalogen score as an independent modifiable marker of metabolic health: population based observational studies and a placebo …

HB Beyene, K Huynh, T Wang, S Paul, M Cinel… - …, 2024 - thelancet.com
Background Decreased levels of circulating ethanolamine plasmalogens [PE (P)], and a
concurrent increase in phosphatidylethanolamine (PE) are consistently reported in various …

Study of the potential neuroprotective effect of Dunaliella salina extract in SH-SY5Y cell model

R Gallego, A Valdés, JD Sánchez-Martínez… - Analytical and …, 2022 - Springer
Alzheimer's disease (AD) is the most common form of dementia caused by a progressive
loss of neurons from different regions of the brain. This multifactorial pathophysiology has …

Mapping the lipidome in mitochondria‐associated membranes (MAMs) in an in vitro model of Alzheimer's disease

T Fernandes, T Melo, T Conde, B Neves… - Journal of …, 2024 - Wiley Online Library
The disruption of mitochondria‐associated endoplasmic reticulum (ER) membranes (MAMs)
plays a relevant role in Alzheimer's disease (AD). MAMs have been implicated in neuronal …

Impact of Vitamin D3 Deficiency on Phosphatidylcholine-/Ethanolamine, Plasmalogen-, Lyso-Phosphatidylcholine-/Ethanolamine, Carnitine- and Triacyl Glyceride …

AA Lauer, LV Griebsch, SM Pilz, D Janitschke… - Biomolecules, 2021 - mdpi.com
Vitamin D3 hypovitaminosis is associated with several neurological diseases such as
Alzheimer's disease, Parkinson's disease or multiple sclerosis but also with other diseases …