Mechanisms and pathology of protein misfolding and aggregation
Despite advances in machine learning-based protein structure prediction, we are still far
from fully understanding how proteins fold into their native conformation. The conventional …
from fully understanding how proteins fold into their native conformation. The conventional …
Protein transmission in neurodegenerative disease
Most neurodegenerative diseases are characterized by the intracellular or extracellular
aggregation of misfolded proteins such as amyloid-β and tau in Alzheimer disease, α …
aggregation of misfolded proteins such as amyloid-β and tau in Alzheimer disease, α …
Disease-specific tau filaments assemble via polymorphic intermediates
Intermediate species in the assembly of amyloid filaments are believed to play a central role
in neurodegenerative diseases and may constitute important targets for therapeutic …
in neurodegenerative diseases and may constitute important targets for therapeutic …
Alzheimer disease pathogenesis: insights from molecular and cellular biology studies of oligomeric Aβ and tau species
XQ Chen, WC Mobley - Frontiers in Neuroscience, 2019 - frontiersin.org
Alzheimer disease (AD) represents an oncoming epidemic that without an effective
treatment promises to exact extraordinary human and financial burdens. Studies of …
treatment promises to exact extraordinary human and financial burdens. Studies of …
Mechanisms of secretion and spreading of pathological tau protein
CA Brunello, M Merezhko, RL Uronen… - Cellular and Molecular …, 2020 - Springer
Accumulation of misfolded and aggregated forms of tau protein in the brain is a
neuropathological hallmark of tauopathies, such as Alzheimer's disease and frontotemporal …
neuropathological hallmark of tauopathies, such as Alzheimer's disease and frontotemporal …
Mechanisms of pathogenic tau and Aβ protein spreading in Alzheimer's disease
P d 'Errico, M Meyer-Luehmann - Frontiers in aging neuroscience, 2020 - frontiersin.org
Alzheimer's disease (AD) is pathologically defined by extracellular accumulation of amyloid-
β (Aβ) peptides generated by the cleavage of amyloid precursor protein (APP), strings of …
β (Aβ) peptides generated by the cleavage of amyloid precursor protein (APP), strings of …
Tau strains shape disease
Tauopathies consist of over 25 different neurodegenerative diseases that include
argyrophilic grain disease (AGD), progressive supranuclear palsy (PSP), corticobasal …
argyrophilic grain disease (AGD), progressive supranuclear palsy (PSP), corticobasal …
Advanced techniques for detecting protein misfolding and aggregation in cellular environments
Protein misfolding and aggregation, a key contributor to the progression of numerous
neurodegenerative diseases, results in functional deficiencies and the creation of harmful …
neurodegenerative diseases, results in functional deficiencies and the creation of harmful …
A walk through tau therapeutic strategies
S Jadhav, J Avila, M Schöll, GG Kovacs… - Acta neuropathologica …, 2019 - Springer
Tau neuronal and glial pathologies drive the clinical presentation of Alzheimer's disease
and related human tauopathies. There is a growing body of evidence indicating that …
and related human tauopathies. There is a growing body of evidence indicating that …
CSF tau microtubule binding region identifies tau tangle and clinical stages of Alzheimer's disease
Tau is a microtubule associated protein in the brain that aggregates in Alzheimer's disease
to form pathological tangles and neurites. Insoluble tau aggregates composed of the …
to form pathological tangles and neurites. Insoluble tau aggregates composed of the …