Active iodide (I−) transport in both the thyroid and some extrathyroidal tissues is mediated by
the Na+/I− symporter (NIS). In the thyroid, NIS-mediated I− uptake plays a pivotal role in …

Abstract The Na+/I− symporter (NIS) is the plasma membrane glycoprotein that mediates
active I− transport in the thyroid and other tissues, such as salivary glands, stomach …

Abstract Thyroid hormones (TH) 3, 5, 3′, 5'-tetraiodothyronine or thyroxine (T4) and 3, 5, 3'-
triiodothyronine (T3) contain iodine atoms as part of their structure, and their synthesis occur …

Abstract The Na+/I− symporter (NIS) is an integral plasma membrane glycoprotein that
mediates active I− transport into the thyroid follicular cells, the first step in thyroid hormone …

Thyroid hormones (THs) are secreted by the thyroid gland. They control lipid, carbohydrate,
and protein metabolism, heart rate, neural development, as well as cardiovascular, renal …

In humans, the kidneys filter∼ 180 g of d-glucose from plasma each day, and this is
normally reabsorbed in the proximal tubules. Although the mechanism of reabsorption is …

There are three families of glucose transporters in the human genome, SLC2, SLC5 and
SLC50. Here I review the structure and function of the SLC5 and SLC50 genes. The human …

The sodium/iodide symporter mediates active iodide transport in both healthy and
cancerous thyroid tissue. By exploiting this activity, radioiodide has been used for decades …

The Na+/I− symporter (NIS) is an intrinsic membrane protein that mediates the active
transport of iodide into the thyroid and other tissues, such as salivary glands, gastric …

The activating mutation BRAFV600E is a frequent genetic event in papillary thyroid
carcinomas (PTC) that predicts a poor prognosis, leading to loss of sodium/iodide symporter …