The huge communities of residential microbes, including bacteria, viruses, Archaea, and
Eukaryotes, that colonize humans are increasingly recognized as playing important roles in …

Tissue sections offer the opportunity to understand a patient's condition, to make better
prognostic evaluations and to select optimum treatments, as evidenced by the place …

Immune-profiling is becoming an important tool to identify predictive markers for the
response to immunotherapy. Our goal was to validate multiplex immunofluorescence (mIF) …

High parameter imaging is an important tool in the life sciences for both discovery and
healthcare applications. Imaging Mass Cytometry (IMC) and Multiplexed Ion Beam Imaging …

Tumors are unique and complex ecosystems, in which heterogeneous cell subpopulations
with variable molecular profiles, aggressiveness, and proliferation potential coexist and …

The emergent field of digital pathology employing automated image analysis techniques is
to revolutionize traditional pathology at the center of clinical diagnostics. Histological images …

The abundance of tumor-infiltrating lymphocytes has been associated with a favorable
prognosis in estrogen receptor-negative breast cancer. However, a high degree of spatial …

Background It is increasingly recognized that cancer progression induces systemic immune
changes in the host. Alterations in number and function of immune cells have been identified …

Multiplex immunofluorescence (mIF) has arisen as an important tool for immuno-profiling
tumor tissues. We updated our manual protocol into an automated protocol that allows the …

Purpose: Although high T-cell density is a well-established favorable prognostic factor in
colorectal cancer, the prognostic significance of tumor-associated plasma cells, neutrophils …