In this" Critical Review" we made a historical introduction of drugs assayed against Chagas
disease beginning in 1912 with the works of Mayer and Rocha Lima up to the experimental …

Chagas disease caused by Trypanosoma cruzi remains an important neglected tropical
disease and a cause of significant morbidity and mortality. No longer confined to endemic …

The major goal of studies on immunity to Trypanosoma cruzi is the understanding of
immunological mechanisms involved in resistance to this protozoan as well as the …

Publisher Summary Among the protozoa of the Trypanosomatidae family, a large number of
species represent agents of diseases, such as Chagas' disease. This chapter reviews some …

This study consists of a broad review on what is known and what should be improved
regarding knowledge of Chagas disease, not only through analysis on the main studies …

Chagas disease, caused by the protozoan Trypanosoma cruzi, is a lifelong and debilitating
illness of major significance throughout Latin America and an emergent threat to global …

Sera of patients with chronic Chagas' disease (American trypanosomiasis) contain elevated
levels of anti-alpha-galactosyl antibodies that are lytic to Trypanosoma cruzi. The T. cruzi …

WSX-1 is a class I cytokine receptor with homology to the IL-12 receptors and is essential for
resistance to Leishmania major infection. In the present study, we demonstrated that WSX-1 …

IL-17A is a key cytokine that induces inflammatory responses through the organized
production of inflammatory cytokines, such as IL-6, TNF-α, and GM-CSF, and induces …

In the acute phase and in the chronic forms of Chagas disease, the etiological diagnosis
may be performed by detection of the parasite using direct or indirect parasitological …