Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …

Polydactyly or polydactylism, also known as a hyperdactyly, is a congenital limb defect with
various morphologic phenotypes. Apart from physical and functional impairments, the …

WNT10B, a member of the WNT family of secreted glycoproteins, activates the WNT/β-
catenin signaling cascade to control proliferation, stemness, pluripotency, and cell fate …

Split-hand/foot malformation (SHFM) is a genetic limb anomaly disturbing the central rays of
the autopod. SHFM is a genetically heterogeneous disorder with variable expressivity …

Background Polydactyly is a common genetic limb deformity characterized by the presence
of extra fingers or toes. This anomaly may occur in isolation (nonsyndromic) or as part of a …

Background: Inherited isolated nail clubbing is a very rare Mendelian condition in humans,
characterized by enlargement of the terminal segments of fingers and toes with thickened …

Genetic skeletal disorders (GSDs) constitute a heterogeneous, rare and a distinctive group
of rare bone growth disorders, leading to abnormal size and shape of the skeleton …

Genetic skeletal disorders (GSDs) are a large group of rare heterogeneous disorders
characterized by abnormal development, remodeling, and growth of the human skeleton's …

Split Hand-Foot Malformation (SHFM) is a congenital limb defect characterized by a median
cleft of the hands and/or feet due to the absence/hypoplasia of the central rays. It may occur …

Disorders that result from de-arrangement of growth, development and/or differentiation of
the appendages (limbs and digit) are collectively called as inherited abnormalities of human …