The skin serves as the body's first line of defense, guarding against mechanical, chemical,
and thermal damage to the interior organs. It includes a highly developed immune response …

Tomentosin is a natural compound known for its presence in some medicinal plants of the
Asteraceae family such as Inula viscosa. Recent studies have highlighted its anticancer and …

ABSTRACT The Ubiquitin-Proteasome System plays a central role in signal transduction
associated with stress, in the skin in particular by the control of NF-κB pathways. Under …

Cancer is a complex disease including approximately 200 different entities that can
potentially affect all body tissues. Among the conventional treatments, radiotherapy and …

Ethnopharmacological relevance The important genus Inula contains more than 100
species and is widespread in the temperate regions of Asia, Africa, and Europe. Numerous …

Dittrichia viscosa is a perennial herb that has been used for generations in traditional
medicine to address a variety of diseases, including diabetes, hypertension, cancer …

Tomentosin, one of natural sesquiterpene lactones sourced from Inula viscosa L., exerts
therapeutic effects in various cell types. Here, we investigated the antioxidant activities and …

Numerous studies have reported the pharmacological effects exhibited by Dittrichia
viscosa,(D. viscosa) including antioxidant, cytotoxic, antiproliferative, and anticancer …

Background Regulatory degradation of intracellular proteins plays an essential role in most
biological processes, particularly in the control of cell proliferation and differentiation. In …

Proteasome inhibitors have effective anti-tumor activity in cell culture and can induce
apoptosis by interfering with the degradation of cell cycle proteins. 20S Proteasome is …