[HTML][HTML] Small molecules, inhibitors of DNA-PK, targeting DNA repair, and beyond
D Davidson, L Amrein, L Panasci… - Frontiers in pharmacology, 2013 - frontiersin.org
Many current chemotherapies function by damaging genomic DNA in rapidly dividing cells
ultimately leading to cell death. This therapeutic approach differentially targets cancer cells …
ultimately leading to cell death. This therapeutic approach differentially targets cancer cells …
Medicinal chemistry of oxazines as promising agents in drug discovery
Oxazines have brought much synthetic interest due to their extensive biological activities.
These are the important category of heterocycles, which may be formally derived from …
These are the important category of heterocycles, which may be formally derived from …
Phosphatidylinositol 3-kinase (PI3K) and phosphatidylinositol 3-kinase-related kinase (PIKK) inhibitors: importance of the morpholine ring
M Andrs, J Korabecny, D Jun, Z Hodny… - Journal of medicinal …, 2015 - ACS Publications
Phosphatidylinositol 3-kinases (PI3Ks) and phosphatidylinositol 3-kinase-related protein
kinases (PIKKs) are two related families of kinases that play key roles in regulation of cell …
kinases (PIKKs) are two related families of kinases that play key roles in regulation of cell …
Design, synthesis of benzimidazole tethered 3, 4-dihydro-2H-benzo [e][1, 3] oxazines as anticancer agents
S Gali, D Raghu, V Mallikanti, V Thumma… - Molecular Diversity, 2024 - Springer
Abstract A series of novel 3-(1H-benzo [d] imidazol-2-yl)-3, 4-dihydro-2H-benzo [e][1, 3]
oxazine analogues synthesized through a two-step synthetic protocol. The structure of the …
oxazine analogues synthesized through a two-step synthetic protocol. The structure of the …
Rational design, synthesis, pharmacophore modeling, and docking studies for identification of novel potent DNA-PK inhibitors
Drugs of cancer based upon ionizing radiation or chemotherapeutic treatment may affect
breaking of DNA double strand in cell. DNA-PK enzyme has emerged as an attractive target …
breaking of DNA double strand in cell. DNA-PK enzyme has emerged as an attractive target …
Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8-and 6-aryl-substituted-1-3-benzoxazines
R Morrison, JMA Al-Rawi, IG Jennings… - European journal of …, 2016 - Elsevier
Abstract The synthesis of 6-aryl, 8-aryl, and 8-aryl-6-chloro-2-morpholino-1, 3-benzoxazines
with potent activity against PI3K and DNA-PK is described. Synthesis of thirty one analogues …
with potent activity against PI3K and DNA-PK is described. Synthesis of thirty one analogues …
Identification of 6-Anilino Imidazo[4,5-c]pyridin-2-ones as Selective DNA-Dependent Protein Kinase Inhibitors and Their Application as Radiosensitizers
CR Hong, LP Liew, WW Wong… - Journal of Medicinal …, 2024 - ACS Publications
The dominant role of non-homologous end-joining in the repair of radiation-induced double-
strand breaks identifies DNA-dependent protein kinase (DNA-PK) as an excellent target for …
strand breaks identifies DNA-dependent protein kinase (DNA-PK) as an excellent target for …
Synthesis, DNA-PK inhibition, anti-platelet activity studies of 2-(N-substituted-3-aminopyridine)-substituted-1, 3-benzoxazines and DNA-PK and PI3K inhibition …
SK Ihmaid, JMA Al-Rawi, CJ Bradley… - European journal of …, 2012 - Elsevier
A number of new 2-(pyridin-3-ylamino)-4H-(substituted) benz [e]-1, 3-oxazin-4-ones were
synthesized 10a–g. These were then reacted with the hydro-halogen salt of 2, 3 and 4-(halo …
synthesized 10a–g. These were then reacted with the hydro-halogen salt of 2, 3 and 4-(halo …
Design, synthesis, docking studies and biological screening of 2-pyrimidinyl-2, 3-dihydro-1H-naphtho [1, 2-e][1, 3] oxazines as potent tubulin polymerization …
A series of novel substituted 2-pyrimidinyl-2, 3-dihydro-1 H-naphtho [1, 2-e][1, 3] oxazine
analogs have been designed and synthesized based on structure-activity relationships from …
analogs have been designed and synthesized based on structure-activity relationships from …
An Inverse Electron Demand Azo-Diels–Alder Reaction of o-Quinone Methides and Imino Ethers: Synthesis of Benzocondensed 1,3-Oxazines
DV Osipov, VA Osyanin, GD Khaysanova… - The Journal of …, 2018 - ACS Publications
We have studied the reactions of o-quinone methide precursors with imino ethers. The
reaction provides a versatile route to substituted 1, 3-benzoxazines. The proposed reaction …
reaction provides a versatile route to substituted 1, 3-benzoxazines. The proposed reaction …