Thioethers: an overview
MI Han, Ŧ Küçükgüzel - Current drug targets, 2022 - ingentaconnect.com
Spreading rapidly in recent years, cancer has become one of the causes of the highest
mortality rates after cardiovascular diseases. The reason for cancer development is still not …
mortality rates after cardiovascular diseases. The reason for cancer development is still not …
Unraveling the chemical profile, antioxidant, enzyme inhibitory, cytotoxic potential of different extracts from Astragalus caraganae
Six extracts (water, ethanol, ethanol‐water, ethyl acetate, dichloromethane, and n‐hexane)
of Astragalus caraganae were studied for their biological activities and bioactive contents …
of Astragalus caraganae were studied for their biological activities and bioactive contents …
Synthesis, molecular modeling, in vivo study and anticancer activity against prostate cancer of (+)(S)-naproxen derivatives
Abstract In this study,(S)-naproxen thiosemicarbazides (3a-d), 1, 2, 4-triazoles (4a-c),
triazole-thioether hybride compounds (5a-p) were synthesized and their structures (3a, 3d …
triazole-thioether hybride compounds (5a-p) were synthesized and their structures (3a, 3d …
Recent progress on apoptotic activity of triazoles
P Çıkla-Süzgün, ŞG Küçükgüzel - Current drug targets, 2021 - ingentaconnect.com
Apoptosis is often called programmed cell death and is defined as a self-directed cell
destruction process. It is different from necrosis due to the activation of caspases during this …
destruction process. It is different from necrosis due to the activation of caspases during this …
Design, synthesis, and in vitro and in vivo anticancer activity studies of new (S)-Naproxen thiosemicarbazide/1, 2, 4-triazole derivatives
In this study, a series of novel (S)-Naproxen derivatives bearing a thiosemicarbazide/1, 2, 4-
triazole moiety were designed, synthesized, and evaluated for anticancer activity. The …
triazole moiety were designed, synthesized, and evaluated for anticancer activity. The …
Identification of potential inhibitors of human methionine aminopeptidase (type II) for cancer therapy: Structure-based virtual screening, ADMET prediction and …
Abstract Methionine Aminopeptidases MetAPs are divalent-cofactor dependent enzymes
that are responsible for the cleavage of the initiator Methionine from the nascent …
that are responsible for the cleavage of the initiator Methionine from the nascent …
Synthesis and molecular modeling of MetAP2 of thiosemicarbazides, 1, 2, 4-triazoles, thioethers derived from (S)-Naproxen as possible breast cancer agents
Abstract New thiosemicarbazides (3, 5-6), 1, 2, 4-triazoles (14-15) and thioethers (22-68)
from derived (S)-Naproxen were synthesized in this study. The structure of these compounds …
from derived (S)-Naproxen were synthesized in this study. The structure of these compounds …
Synthesis of Novel (S)-Flurbiprofen-based Esters for Cancer Treatment by Targeting Thymidine Phosphorylase via Biomolecular Approaches
The current work is based on the synthesis of novel ester derivatives (1-17) of commercially
available drug flurbiprofen by using two methods. In the first method, CDI (1, 1 …
available drug flurbiprofen by using two methods. In the first method, CDI (1, 1 …
[PDF][PDF] In silico studies and in vitro microsomal metabolism of potent MetAP2 inhibitor and in vivo tumor suppressor for prostate cancer: A thioether-triazole hybrid
Materials and methods: In the present study, the sulfoxide metabolite was synthesized,
purified and characterized by chromatographic and spectroscopic methods. SGK636, the S …
purified and characterized by chromatographic and spectroscopic methods. SGK636, the S …
Effect of flurbiprofen derivative (SGK597) on cell proliferation and apoptosis of breast cancer cell lines
Background and Aims: The incidence of breast cancer is increasing day by day, especially
in women. The search for new drugs against breast cancer is the focus of attention in …
in women. The search for new drugs against breast cancer is the focus of attention in …