The mononuclear phagocyte system of the rat
The laboratory rat continues to be the model of choice for many studies of physiology,
behavior, and complex human diseases. Cells of the mononuclear phagocyte system (MPS; …
behavior, and complex human diseases. Cells of the mononuclear phagocyte system (MPS; …
Targeting the NLRP3 inflammasome for the treatment of hypertensive target organ damage: Role of natural products and formulations
X Liao, Y Han, C Shen, J Liu, Y Wang - Phytotherapy Research, 2023 - Wiley Online Library
Abstract Background and Aim Hypertension is a major global health problem that causes
target organ damage (TOD) in the heart, brain, kidney, and blood vessels. The mechanisms …
target organ damage (TOD) in the heart, brain, kidney, and blood vessels. The mechanisms …
Luseogliflozin, a sodium-glucose cotransporter-2 inhibitor, reverses cerebrovascular dysfunction and cognitive impairments in 18-mo-old diabetic animals
Diabetes mellitus (DM) is a leading risk factor for age-related dementia, but the mechanisms
involved are not well understood. We previously discovered that hyperglycemia induced …
involved are not well understood. We previously discovered that hyperglycemia induced …
Renoprotective effects of empagliflozin in type 1 and type 2 models of diabetic nephropathy superimposed with hypertension
Diabetes, hypertension, and aging are major contributors to cardiovascular and chronic
kidney disease (CKD). Sodium/glucose cotransporter 2 (SGLT2) inhibitors have become a …
kidney disease (CKD). Sodium/glucose cotransporter 2 (SGLT2) inhibitors have become a …
Endoplasmic reticulum stress increases DUSP5 expression via PERK-CHOP pathway, leading to hepatocyte death
Hepatocyte death is critical for the pathogenesis of liver disease progression, which is
closely associated with endoplasmic reticulum (ER) stress responses. However, the …
closely associated with endoplasmic reticulum (ER) stress responses. However, the …
Longitudinal characterization of cerebral hemodynamics in the TgF344-AD rat model of Alzheimer's disease
Alzheimer's disease (AD) is a global healthcare crisis. The TgF344-AD rat is an AD model
exhibiting age-dependent AD pathological hallmarks. We confirmed that AD rats developed …
exhibiting age-dependent AD pathological hallmarks. We confirmed that AD rats developed …
Influence of dual‐specificity protein phosphatase 5 on mechanical properties of rat cerebral and renal arterioles
We recently reported that KO of Dual‐specificity protein phosphatase 5 (Dusp5) enhances
myogenic reactivity and blood flow autoregulation in the cerebral and renal circulations in …
myogenic reactivity and blood flow autoregulation in the cerebral and renal circulations in …
Genetic susceptibility of hypertension‐induced kidney disease
Hypertension is the second leading cause of end‐stage renal disease (ESRD) after diabetes
mellitus. The significant differences in the incidence of hypertensive ESRD between different …
mellitus. The significant differences in the incidence of hypertensive ESRD between different …
[HTML][HTML] Enhanced cerebral hemodynamics and cognitive function via knockout of dual-specificity protein phosphatase 5
Alzheimer's Disease (AD) and Alzheimer's Disease-Related Dementias (ADRD) are
neurodegenerative disorders. Recent studies suggest that cerebral hypoperfusion is an …
neurodegenerative disorders. Recent studies suggest that cerebral hypoperfusion is an …
Role of γ-adducin in actin cytoskeleton rearrangements in podocyte pathophysiology
We recently reported that the enhanced susceptibility to chronic kidney disease (CKD) in the
fawn-hooded hypertensive (FHH) rat is caused, at least in part, by a mutation in γ-adducin …
fawn-hooded hypertensive (FHH) rat is caused, at least in part, by a mutation in γ-adducin …