Delirium is a neurocognitive syndrome arising from acute global brain dysfunction, and is
prevalent in up to 42% of patients admitted to palliative care inpatient units. The symptoms of …

Abstract Learning Objectives After completing this course, the reader will be able to:
Summarize the current evidence regarding strategies for the assessment and management …

In the present study, haloperidol (HP)-loaded solid lipid nanoparticles (SLNs) were prepared
to enhance the uptake of HP to brain via intranasal (in) delivery. SLNs were prepared by a …

Background In end-of-life care, symptoms of discomfort are mainly managed by drug
therapy, the guidelines for which are mainly based on expert opinions. A few papers have …

Opioids, defined as drugs that stimulate opioid receptors, are primarily used in the treatment
of moderate to severe pain. They induce central nervous system (CNS) adverse effects …

Delirium is a common problem and cause of distress among patients with palliative care
needs. The focus to date has been on managing the patient with agitated, hyperactive …

Aims QTc interval‐prolonging drugs have been linked to cardiac arrhythmias, cardiac arrest
and sudden death. In this study we aimed to quantify the risk of cardiac arrest associated …

Continuous deep sedation at the end of life is a specific form of palliative sedation requiring
a care plan that essentially places and maintains the patient in an unresponsive state …

Context Delirium is a highly prevalent complication in patients in palliative care settings,
especially in the end-of-life context. Objectives To review the current evidence base for …

Background Continuous sedation, contrary to euthanasia, has been increasingly accepted
among medical professionals worldwide. In the Netherlands, a national guideline for …