Lipid and Carbohydrate Metabolism in Caenorhabditis elegans
Lipid and carbohydrate metabolism are highly conserved processes that affect nearly all
aspects of organismal biology. Caenorhabditis elegans eat bacteria, which consist of lipids …
aspects of organismal biology. Caenorhabditis elegans eat bacteria, which consist of lipids …
[HTML][HTML] Application of Caenorhabditis elegans in Lipid Metabolism Research
L An, X Fu, J Chen, J Ma - International journal of molecular sciences, 2023 - mdpi.com
Over the last decade, the development and prevalence of obesity have posed a serious
public health risk, which has prompted studies on the regulation of adiposity. With the ease …
public health risk, which has prompted studies on the regulation of adiposity. With the ease …
[HTML][HTML] An ancient, unified mechanism for metformin growth inhibition in C. elegans and cancer
Metformin has utility in cancer prevention and treatment, though the mechanisms for these
effects remain elusive. Through genetic screening in C. elegans, we uncover two metformin …
effects remain elusive. Through genetic screening in C. elegans, we uncover two metformin …
Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan
Chromatin and metabolic states both influence lifespan, but how they interact in lifespan
regulation is largely unknown. The COMPASS chromatin complex, which trimethylates …
regulation is largely unknown. The COMPASS chromatin complex, which trimethylates …
Quantification of lipid abundance and evaluation of lipid distribution in Caenorhabditis elegans by nile red and oil red O staining
Caenorhabditis elegans is an exceptional model organism in which to study lipid
metabolism and energy homeostasis. Many of its lipid genes are conserved in humans and …
metabolism and energy homeostasis. Many of its lipid genes are conserved in humans and …
[HTML][HTML] Early-life vitamin B12 orchestrates lipid peroxidation to ensure reproductive success via SBP-1/SREBP1 in Caenorhabditis elegans
Summary Vitamin B12 (B12) deficiency is a critical problem worldwide. Such deficiency in
infants has long been known to increase the propensity to develop obesity and diabetes …
infants has long been known to increase the propensity to develop obesity and diabetes …
[HTML][HTML] SKN-1 and Nrf2 couples proline catabolism with lipid metabolism during nutrient deprivation
S Pang, DA Lynn, JY Lo, J Paek, SP Curran - Nature communications, 2014 - nature.com
Mechanisms that coordinate different metabolic pathways, such as glucose and lipid, have
been recognized. However, a potential interaction between amino acid and lipid metabolism …
been recognized. However, a potential interaction between amino acid and lipid metabolism …
Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infection
JD Nhan, CD Turner, SM Anderson… - Proceedings of the …, 2019 - National Acad Sciences
Early host responses toward pathogens are essential for defense against infection. In
Caenorhabditis elegans, the transcription factor, SKN-1, regulates cellular defenses during …
Caenorhabditis elegans, the transcription factor, SKN-1, regulates cellular defenses during …
[HTML][HTML] The fatty acid oleate is required for innate immune activation and pathogen defense in Caenorhabditis elegans
SM Anderson, HK Cheesman, ND Peterson… - PLoS …, 2019 - journals.plos.org
Fatty acids affect a number of physiological processes, in addition to forming the building
blocks of membranes and body fat stores. In this study, we uncover a role for the …
blocks of membranes and body fat stores. In this study, we uncover a role for the …
Di (2-ethylhexyl) phthalate and diethyl phthalate disrupt lipid metabolism, reduce fecundity and shortens lifespan of Caenorhabditis elegans
The widespread use of phthalates is of major concern as they have adverse effects on many
different physiological functions, including reproduction, metabolism and cell differentiation …
different physiological functions, including reproduction, metabolism and cell differentiation …