In the early 1980s, two water-supply systems on the Marine Corps Base Camp Lejeune in
North Carolina were found to be contaminated with the industrial solvents trichloroethylene …

In the 1940s and 1950s the hypothesis first developed that many drugs, industrial chemicals,
pesticides, pollutants, and other materials are not toxic per se but elicit their effects only after …

Publisher Summary This chapter discusses the role of glutathione (GSH) and glutathione s-
transferases in metabolism of chemical carcinogens and other electrophilic agents. GSH is a …

Toxins are natural or chemical poisonous substances with severe side effects on health.
Humans are generally exposed by widespread toxic contaminations via air, soil, water, food …

Publisher Summary The method for lowering tissue glutathione (GSH) levels involves the
administration of compounds that react enzymically with GSH to form conjugates. The …

Experience with dose response and mechanisms of toxicity has shown that multiple
mechanisms may exist for a single agent along the continuum of the full dose–response …

Trichloroethylene (TCE) has been an industrial chemical of some importance for the past 50
years. First synthesized by Fischer in 1864, TCE has enjoyed considerable industrial usage …

Administration of phorone (diisopropylidene acetone), an industrial solvent, to mice caused
a rapid depletion of hepatic glutathione, which is due to enzymatic conjugation of phorone …

The hepatotoxic response elicited by a chemical agent depends on the concentration of the
toxicant (parent compound or metaholite) delivered to the hepatocytes across the liver …

Acetaminophen and bromobenzene are transformed in the liver into chemically reactive
metabolites that may either bind to glutathione and be detoxified or bind to hepatic proteins …