TGF‐β signalling and liver disease

I Fabregat, J Moreno‐Càceres, A Sánchez… - The FEBS …, 2016 - Wiley Online Library
The transforming growth factor‐beta (TGF‐β) family signalling pathways play essential roles
in the regulation of different cellular processes, including proliferation, differentiation …

Targeting mitosis in cancer: emerging strategies

C Dominguez-Brauer, KL Thu, JM Mason, H Blaser… - Molecular cell, 2015 - cell.com
The cell cycle is an evolutionarily conserved process necessary for mammalian cell growth
and development. Because cell-cycle aberrations are a hallmark of cancer, this process has …

Pubchem bioassay: 2017 update

Y Wang, SH Bryant, T Cheng, J Wang… - Nucleic acids …, 2017 - academic.oup.com
PubChem's BioAssay database (https://pubchem. ncbi. nlm. nih. gov) has served as a public
repository for small-molecule and RNAi screening data since 2004 providing open access of …

Omega-3 polyunsaturated fatty acids as a treatment strategy for nonalcoholic fatty liver disease

DB Jump, KA Lytle, CM Depner, S Tripathy - Pharmacology & therapeutics, 2018 - Elsevier
Obese and type 2 diabetic (T2DM) patients have a high prevalence of nonalcoholic fatty liver
disease (NAFLD). NAFLD is a continuum of chronic liver diseases ranging from benign …

Impact of novel miR-145-3p regulatory networks on survival in patients with castration-resistant prostate cancer

Y Goto, A Kurozumi, T Arai, N Nohata, S Kojima… - British journal of …, 2017 - nature.com
Background: Despite recent advancements, metastatic castration-resistant prostate cancer
(CRPC) is not considered curative. Novel approaches for identification of therapeutic targets …

[HTML][HTML] Mutual regulation of TGFβ-induced oncogenic EMT, cell cycle progression and the DDR

H Schuhwerk, T Brabletz - Seminars in Cancer Biology, 2023 - Elsevier
TGFβ signaling and the DNA damage response (DDR) are two cellular toolboxes with a
strong impact on cancer biology. While TGFβ as a pleiotropic cytokine affects essentially all …

The expanding phenotypes of cohesinopathies: one ring to rule them all!

J Piché, PP Van Vliet, M Pucéat, G Andelfinger - Cell Cycle, 2019 - Taylor & Francis
Preservation and development of life depend on the adequate segregation of sister
chromatids during mitosis and meiosis. This process is ensured by the cohesin multi-subunit …

Key signaling networks are dysregulated in patients with the adipose tissue disorder, lipedema

M Ishaq, N Bandara, S Morgan, C Nowell… - International Journal of …, 2022 - nature.com
Objectives Lipedema, a poorly understood chronic disease of adipose hyper-deposition, is
often mistaken for obesity and causes significant impairment to mobility and quality-of-life …

Therapeutic targeting of TGF‐β in lung cancer

S Aftabi, A Barzegar Behrooz, M Cordani… - The FEBS …, 2024 - Wiley Online Library
Transforming growth factor‐β (TGF‐β) plays a complex role in lung cancer pathophysiology,
initially acting as a tumor suppressor by inhibiting early‐stage tumor growth. However, its …

Nuclear PD-L1 promotes cell cycle progression of BRAF-mutated colorectal cancer by inhibiting THRAP3

R Ma, Y Liu, X Che, C Li, T Wen, K Hou, X Qu - Cancer Letters, 2022 - Elsevier
Colorectal cancers (CRCs) with the BRAF V600E mutation exhibit upregulation of
programmed death ligand 1 (PD-L1) but fail to respond to immunotherapy targeting …