CD24 is a highly glycosylated protein with a small protein core that is linked to the plasma
membrane via a glycosyl‐phosphatidylinositol anchor. CD24 is primarily expressed by …

Cancer immunotherapy in the form of immune checkpoint inhibitors and cellular therapies
has improved the treatment and prognosis of many patients. Nevertheless, most cancers are …

Sciatic nerve crush injury triggers sterile inflammation within the distal nerve and axotomized
dorsal root ganglia (DRGs). Granulocytes and pro-inflammatory Ly6Chigh monocytes …

The mammalian immune system evolved to tightly regulate the elimination of pathogenic
microbes and neoplastic transformed cells while tolerating our own healthy cells. Here, we …

Sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of receptors that
recognize sialoglycans–sialic acid containing glycans that are abundantly present on cell …

Anemia of inflammation, also known as anemia of chronic disease, is refractory to
erythropoietin (EPO) treatment, but the mechanisms underlying the EPO refractory state are …

The disruption of the immune tolerance induces autoimmunity such as systemic lupus
erythematosus and vasculitis. A chromatin-binding non-histone protein, high mobility group …

High mobility group box-1 protein (HMGB1), a member of the high mobility group protein
superfamily, is an abundant and ubiquitously expressed nuclear protein. Intracellular …

Existing immune checkpoint inhibitors focus on activating T cells and show limited
effectiveness in gastric cancer (GC). SIGLEC10 is identified as a novel tumor-associated …

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease, notably resistant to existing
therapies. Current research indicates that PDAC patients deficient in homologous …