The human virome: assembly, composition and host interactions

G Liang, FD Bushman - Nature Reviews Microbiology, 2021 - nature.com
The human body hosts vast microbial communities, termed the microbiome. Less well
known is the fact that the human body also hosts vast numbers of different viruses …

Bacteriophages and the immune system

M Popescu, JD Van Belleghem… - Annual review of …, 2021 - annualreviews.org
Bacteriophages—viruses that infect bacteria—are abundant within our bodies, but their
significance to human health is only beginning to be explored. Here, we synthesize what is …

Immunogenicity of bacteriophages

K Champagne-Jorgensen, T Luong, T Darby… - Trends in …, 2023 - cell.com
Hundreds of trillions of diverse bacteriophages (phages) peacefully thrive within and on the
human body. However, whether and how phages influence their mammalian hosts is poorly …

A Mammalian Cell's Guide on How to Process a Bacteriophage

L Kan, JJ Barr - Annual Review of Virology, 2023 - annualreviews.org
Bacteriophages are enigmatic entities that defy definition. Classically, they are specialist
viruses that exclusively parasitize bacterial hosts. Yet this definition becomes limiting when …

The safety and efficacy of phage therapy: a systematic review of clinical and safety trials

HJ Stacey, S De Soir, JD Jones - Antibiotics, 2022 - mdpi.com
Trials of phage therapy have not consistently reported efficacy. This contrasts with promising
efficacy rates from a sizeable and compelling body of observational literature. This …

Bacteriophage uptake by mammalian cell layers represents a potential sink that may impact phage therapy

MC Bichet, WH Chin, W Richards, YW Lin… - Iscience, 2021 - cell.com
It is increasingly apparent that bacteriophages, viruses that infect bacteria and more
commonly referred to as simply phages, have tropisms outside their bacterial hosts. Using …

Unraveling the viral dark matter through viral metagenomics

TM Santiago-Rodriguez, EB Hollister - Frontiers in immunology, 2022 - frontiersin.org
Viruses are part of the microbiome and have essential roles in immunology, evolution,
biogeochemical cycles, health, and disease progression. Viruses influence a wide variety of …

Interactions of bacteriophages with animal and human organisms—safety issues in the light of phage therapy

M Podlacha, Ł Grabowski… - International journal of …, 2021 - mdpi.com
Bacteriophages are viruses infecting bacterial cells. Since there is a lack of specific
receptors for bacteriophages on eukaryotic cells, these viruses were for a long time …

Diversity of vaginal microbiome in pregnancy: deciphering the obscurity

P Gupta, MP Singh, K Goyal - Frontiers in public health, 2020 - frontiersin.org
Human microbiota plays an indispensable role in physiology, nutrition and most
significantly, in imparting immunity. The role of microbiota has remained cryptic for years …

The presence of bacteriophages in the human body: good, bad or neutral?

M Łusiak-Szelachowska, B Weber-Dąbrowska… - Microorganisms, 2020 - mdpi.com
The presence of bacteriophages (phages) in the human body may impact bacterial
microbiota and modulate immunity. The role of phages in human microbiome studies and …