The CDKN2A/B genomic locus is associated with risk of human cancers and metabolic
disease. Although the locus contains several important protein-coding genes, studies …

Loss of the tumor suppressor gene CDKN2A, encoding p16 and p14, is a frequent event
driving melanoma progression. Therefore, therapeutic strategies aimed at CDKN2A loss …

Uveal melanoma (UM) and retinoblastoma (RB), which cause blindness and even death,
are the most frequently observed primary intraocular malignancies in adults and children …

Cancer is the second leading cause of death worldwide, despite recent advances in its
identification and management. To improve cancer patient diagnosis and care, it is …

Because of the lack of sensitivity to radiotherapy and chemotherapy, therapeutic options for
renal clear cell carcinoma (KIRC) are scarce. Long noncoding RNAs (lncRNAs) play crucial …

Melanoma, a malignant form of skin cancer, has been swiftly increasing in recent years.
Although there have been significant advancements in clinical treatment underlying a well …

Melanoma is the most lethal cutaneous cancer with a highly aggressive and metastatic
phenotype. While recent genetic and epigenetic studies have shed new insights into the …

Simple Summary Uveal melanoma (UM) is a rare eye cancer with a high mortality rate due
to metastases, leading to death in up to 50% of patients within 10 years from UM diagnosis …

Autophagy plays an adaptive role in cell survival, development, differentiation and
intracellular homeostasis. Autophagy is recognized as a'self-cannibalizing'process that is …

Oral squamous cell carcinoma (OSCC) is a common malignant disease associated with a
high mortality rate and heterogeneous disease aetiology. Cyclin dependent kinase inhibitor …