Transcriptome-wide association studies: recent advances in methods, applications and available databases
Genome-wide association study has identified fruitful variants impacting heritable traits.
Nevertheless, identifying critical genes underlying those significant variants has been a …
Nevertheless, identifying critical genes underlying those significant variants has been a …
Biological role of unsaturated fatty acid desaturases in health and disease
A Czumaj, T Śledziński - Nutrients, 2020 - mdpi.com
Polyunsaturated fatty acids (PUFAs) are considered one of the most important components
of cells that influence normal development and function of many organisms, both eukaryotes …
of cells that influence normal development and function of many organisms, both eukaryotes …
Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics
Inhibition of sclerostin is a therapeutic approach to lowering fracture risk in patients with
osteoporosis. However, data from phase 3 randomized controlled trials (RCTs) of …
osteoporosis. However, data from phase 3 randomized controlled trials (RCTs) of …
Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer's dementia
Transcriptome-wide association studies (TWAS) have been widely used to integrate
transcriptomic and genetic data to study complex human diseases. Within a test dataset …
transcriptomic and genetic data to study complex human diseases. Within a test dataset …
Transcriptome prediction performance across machine learning models and diverse ancestries
Transcriptome prediction methods such as PrediXcan and FUSION have become popular in
complex trait mapping. Most transcriptome prediction models have been trained in …
complex trait mapping. Most transcriptome prediction models have been trained in …
[HTML][HTML] Potential drug targets for myocardial infarction identified through Mendelian randomization analysis and Genetic colocalization
J Wu, Q Fan, Q He, Q Zhong, X Zhu, H Cai, X He, Y Xu… - Medicine, 2023 - journals.lww.com
Myocardial infarction (MI) is a major cause of death and disability worldwide, but current
treatments are limited by their invasiveness, side effects, and lack of efficacy. Novel drug …
treatments are limited by their invasiveness, side effects, and lack of efficacy. Novel drug …
Transcriptome-wide association study of blood cell traits in african ancestry and hispanic/latino populations
Background: Thousands of genetic variants have been associated with hematological traits,
though target genes remain unknown at most loci. Moreover, limited analyses have been …
though target genes remain unknown at most loci. Moreover, limited analyses have been …
Population-Matched transcriptome prediction increases TWAS discovery and replication rate
E Geoffroy, I Gregga, HE Wheeler - IScience, 2020 - cell.com
Most genome-wide association studies (GWAS) and transcriptome-wide association studies
(TWAS) focus on European populations; however, these results cannot always be accurately …
(TWAS) focus on European populations; however, these results cannot always be accurately …
Advancements in genetic research by the Hispanic Community Health Study/Study of Latinos: A 10-year retrospective review
The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a multicenter,
longitudinal cohort study designed to evaluate environmental, lifestyle, and genetic risk …
longitudinal cohort study designed to evaluate environmental, lifestyle, and genetic risk …
Genomic study of maternal lipid traits in early pregnancy concurs with four known adult lipid loci
Background Blood lipids during pregnancy are associated with cardiovascular diseases and
adverse pregnancy outcomes. Genome-wide association studies (GWAS) in predominantly …
adverse pregnancy outcomes. Genome-wide association studies (GWAS) in predominantly …