From NASH to HCC: current concepts and future challenges
Caloric excess and sedentary lifestyle have led to a global epidemic of obesity and
metabolic syndrome. The hepatic consequence of metabolic syndrome and obesity …
metabolic syndrome. The hepatic consequence of metabolic syndrome and obesity …
Pathophysiological communication between hepatocytes and non-parenchymal cells in liver injury from NAFLD to liver fibrosis
S Kumar, Q Duan, R Wu, EN Harris, Q Su - Advanced drug delivery reviews, 2021 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disease that encompasses a
spectrum of pathological conditions, ranging from simple steatosis (NAFL), nonalcoholic …
spectrum of pathological conditions, ranging from simple steatosis (NAFL), nonalcoholic …
Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis
The mechanisms that drive nonalcoholic fatty liver disease (NAFLD) remain incompletely
understood. This large multicenter study characterized the transcriptional changes that occur …
understood. This large multicenter study characterized the transcriptional changes that occur …
Mechanisms of fibrosis development in nonalcoholic steatohepatitis
Nonalcoholic fatty liver disease is the most prevalent liver disease worldwide, affecting 20%–
25% of the adult population. In 25% of patients, nonalcoholic fatty liver disease progresses …
25% of the adult population. In 25% of patients, nonalcoholic fatty liver disease progresses …
The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)
Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent and represents a growing
challenge in terms of prevention and treatment. Despite its high prevalence, only a small …
challenge in terms of prevention and treatment. Despite its high prevalence, only a small …
A simple diet-and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer
T Tsuchida, YA Lee, N Fujiwara, M Ybanez, B Allen… - Journal of …, 2018 - Elsevier
Background and Aims Although the majority of patients with non-alcoholic fatty liver disease
(NAFLD) have only steatosis without progression, a sizeable fraction develop non-alcoholic …
(NAFLD) have only steatosis without progression, a sizeable fraction develop non-alcoholic …
[HTML][HTML] Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication
Liver fibrosis is a strong predictor of long-term mortality in individuals with metabolic-
associated fatty liver disease; yet, the mechanisms underlying the progression from the …
associated fatty liver disease; yet, the mechanisms underlying the progression from the …
[HTML][HTML] Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies
The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …
public health burden worldwide. The most common form of NCD is metabolic diseases …
Sphingolipids and phospholipids in insulin resistance and related metabolic disorders
PJ Meikle, SA Summers - Nature Reviews Endocrinology, 2017 - nature.com
Obesity, insulin resistance, type 2 diabetes mellitus and cardiovascular disease form a
metabolic disease continuum that has seen a dramatic increase in prevalence in developed …
metabolic disease continuum that has seen a dramatic increase in prevalence in developed …
The role and regulation of the peroxisome proliferator activated receptor alpha in human liver
S Kersten, R Stienstra - Biochimie, 2017 - Elsevier
The peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription
factor that is abundantly expressed in liver. PPARα is activated by fatty acids and various …
factor that is abundantly expressed in liver. PPARα is activated by fatty acids and various …