The EBJIS definition of periprosthetic joint infection: a practical guide for clinicians

M McNally, R Sousa… - The bone & joint …, 2021 - boneandjoint.org.uk
Aims The diagnosis of periprosthetic joint infection (PJI) can be difficult. All current
diagnostic tests have problems with accuracy and interpretation of results. Many new tests …

Fracture-related infection

TF Moriarty, WJ Metsemakers, M Morgenstern… - Nature Reviews …, 2022 - nature.com
Musculoskeletal trauma leading to broken and damaged bones and soft tissues can be a life-
threating event. Modern orthopaedic trauma surgery, combined with innovation in medical …

Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae

A Eskenazi, C Lood, J Wubbolts, M Hites… - Nature …, 2022 - nature.com
A 30-year-old bombing victim with a fracture-related pandrug-resistant Klebsiella
pneumoniae infection after long-term (> 700 days) antibiotic therapy is treated with a pre …

[HTML][HTML] Diagnosing fracture-related infection: current concepts and recommendations

GAM Govaert, R Kuehl, BL Atkins… - … of orthopaedic trauma, 2020 - journals.lww.com
Fracture-related infection (FRI) is a severe complication after bone injury and can pose a
serious diagnostic challenge. Overall, there is a limited amount of scientific evidence …

General treatment principles for fracture-related infection: recommendations from an international expert group

WJ Metsemakers, M Morgenstern, E Senneville… - Archives of Orthopaedic …, 2020 - Springer
Fracture-related infection (FRI) remains a challenging complication that creates a heavy
burden for orthopaedic trauma patients, their families and treating physicians, as well as for …

[HTML][HTML] Pathogenesis and management of fracture-related infection

M Depypere, M Morgenstern, R Kuehl… - Clinical Microbiology …, 2020 - Elsevier
Background Both fracture-related infections (FRIs) and periprosthetic joint infections (PJIs)
include orthopaedic implant-associated infections. However, key aspects of management …

Chronic implant-related bone infections—can immune modulation be a therapeutic strategy?

E Seebach, KF Kubatzky - Frontiers in immunology, 2019 - frontiersin.org
Chronic implant-related bone infections are a major problem in orthopedic and trauma-
related surgery with severe consequences for the affected patients. As antibiotic resistance …

Mechanisms of Immune Evasion and Bone Tissue Colonization That Make Staphylococcus aureus the Primary Pathogen in Osteomyelitis

G Muthukrishnan, EA Masters, JL Daiss… - Current osteoporosis …, 2019 - Springer
Abstract Purpose of Review Staphylococcus aureus is the primary pathogen responsible for
osteomyelitis, which remains a major healthcare burden. To understand its dominance, here …

Skin antisepsis before surgical fixation of extremity fractures

PREP-IT Investigators - New England Journal of Medicine, 2024 - Mass Medical Soc
Background Studies evaluating surgical-site infection have had conflicting results with
respect to the use of alcohol solutions containing iodine povacrylex or chlorhexidine …

The effect of local antibiotic prophylaxis when treating open limb fractures: a systematic review and meta-analysis

M Morgenstern, A Vallejo, MA McNally… - Bone & joint …, 2018 - boneandjoint.org.uk
Objectives As well as debridement and irrigation, soft-tissue coverage, and osseous
stabilization, systemic antibiotic prophylaxis is considered the benchmark in the …