Inwardly rectifying K+ (Kir) channels allow K+ to move more easily into rather than out of the
cell. They have diverse physiological functions depending on their type and their location …

During even the most quiescent behavioral periods, the cortex and thalamus express rich
spontaneous activity in the form of slow (< 1 Hz), synchronous network state transitions …

Glucose is the mandatory fuel for the brain, yet the relative contribution of glucose and
lactate for neuronal energy metabolism is unclear. We found that increased lactate, but not …

The properties and roles of ATP-sensitive (KATP) and inwardly rectifying (KIR) potassium
channels are reviewed. Potassium channels regulate the membrane potential of smooth …

We have cloned an isoform of the sulfonylurea receptor (SUR), designated SUR2.
Coexpression of SUR2 and the inward rectifier K+ channel subunit Kir6. 2 in COS1 cells …

Vasodilators are used clinically for the treatment of hypertension and heart failure. The
effects of some vasodilators seem to be mediated by membrane hyperpolarization. The …

ATP-sensitive potassium (KATP) channels are present in many tissues, including pancreatic
islet cells, heart, skeletal muscle, vascular smooth muscle, and brain, in which they couple …

Glucose-responsive (GR) neurons in the hypothalamus are thought to be critical in glucose
homeostasis, but it is not known how they function in this context. Kir6. 2 is the pore-forming …

Abstract Aguilar-Bryan, Lydia, John P. Clement IV, Gabriela Gonzalez, Kumud Kunjilwar,
Andrey Babenko, and Joseph Bryan. Toward Understanding the Assembly and Structure of …

Preconditioning with sublethal ischemia protects against neuronal damage after subsequent
lethal ischemic insults in hippocampal neurons. A pharmacological approach using agonists …