Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …

Transplantation is often the last resort for end-stage organ failures, eg, kidney, liver, heart,
lung, and pancreas. The shortage of donor organs is the main limiting factor for successful …

Despite the growing recognition of the complement system as a major contributor to a variety
of clinical conditions, the therapeutic arsenal has remained scarce. The introduction of an …

Antiangiogenesis therapies targeting vascular endothelial growth factor (VEGF) have
revolutionized the treatment of neovascular ocular diseases, including neovascular age …

Background Gingivitis and periodontitis are prevalent inflammatory diseases of the
periodontal tissues. Current treatments are often ineffective or do not prevent disease …

The complement system is paramount in the clearance of pathogens and cell debris, yet is
increasingly recognized as a key component in several pathways leading to allograft injury …

Kidney transplantation is the therapy of choice for patients who suffer from end-stage renal
diseases. Despite improvements in surgical techniques and immunosuppressive treatments …

Aberrant activation of the complement system contributes to solid-organ graft dysfunction
and failure. In kidney transplantation, the complement system is implicated in the …

Antibody-mediated rejection (ABMR) is associated with poor transplant outcomes and was
identified as a leading cause of graft failure after kidney transplantation. Although the …

Current desensitization and maintenance immunosuppression regimens for kidney
transplantation in sensitized individuals show limited ability to control the posttransplant …