Clinical trials in progressive multiple sclerosis: lessons learned and future perspectives

D Ontaneda, RJ Fox, J Chataway - The Lancet Neurology, 2015 - thelancet.com
Progressive multiple sclerosis is characterised clinically by the gradual accrual of disability
independent of relapses and can occur with disease onset (primary progressive) or can be …

Optical coherence tomography (OCT) in neuro-ophthalmology

N Minakaran, ER de Carvalho, A Petzold, SH Wong - Eye, 2021 - nature.com
Optical coherence tomography (OCT) is a non-invasive medical imaging technology that is
playing an increasing role in the routine assessment and management of patients with …

Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study

EH Martinez-Lapiscina, S Arnow, JA Wilson… - The Lancet …, 2016 - thelancet.com
Background Most patients with multiple sclerosis without previous optic neuritis have thinner
retinal layers than healthy controls. We assessed the role of peripapillary retinal nerve fibre …

Optical coherence tomography angiography enhances the detection of optic nerve damage in multiple sclerosis

RI Spain, L Liu, X Zhang, Y Jia, O Tan… - British Journal of …, 2018 - bjo.bmj.com
Background Quantitative assessment of optic nerve damage is important in the evaluation of
optic neuritis (ON) and multiple sclerosis (MS). Objective To detect optic nerve damage …

The use of optical coherence tomography in neurology: a review

JS Xie, L Donaldson, E Margolin - Brain, 2022 - academic.oup.com
Optical coherence tomography is a non-invasive, cost-efficient technique that provides high-
resolution in vivo imaging of retinal tissue. The peripapillary retinal nerve fibre layer and …

Retinal imaging with optical coherence tomography: a biomarker in multiple sclerosis?

F Costello, JM Burton - Eye and brain, 2018 - Taylor & Francis
Multiple sclerosis (MS) is a progressive neurological disorder characterized by both
inflammatory and degenerative components that affect genetically susceptible individuals …

Treatment of patients with multiple sclerosis transitioning between relapsing and progressive disease

NG Dimitriou, SG Meuth, EH Martinez-Lapiscina… - CNS drugs, 2023 - Springer
Multiple sclerosis (MS) is a chronic autoimmune demyelinating and neurodegenerative
disease of the central nervous system with a wide variety of clinical phenotypes. In spite of …

Peripapillary retinal nerve fibre layer as measured by optical coherence tomography is a prognostic biomarker not only for physical but also for cognitive disability …

G Bsteh, H Hegen, B Teuchner… - Multiple Sclerosis …, 2019 - journals.sagepub.com
Background: Peripapillary retinal nerve fibre layer (pRNFL) thickness is emerging as a
marker of axonal degeneration in multiple sclerosis (MS). Objective: We aimed to …

Retinal measurements predict 10‐year disability in multiple sclerosis

A Rothman, OC Murphy, KC Fitzgerald… - Annals of Clinical …, 2019 - Wiley Online Library
Objective Optical coherence tomography (OCT)‐derived measures of the retina correlate
with disability and cortical gray matter atrophy in multiple sclerosis (MS); however, whether …

Macular ganglion cell–inner plexiform layer thinning as a biomarker of disability progression in relapsing multiple sclerosis

G Bsteh, K Berek, H Hegen, P Altmann… - Multiple Sclerosis …, 2021 - journals.sagepub.com
Background: Macular ganglion cell–inner plexiform layer (mGCIPL) is an emerging
biomarker of neuroaxonal degeneration in multiple sclerosis (MS). Objective: We aimed to …