Severe combined immunodeficiencies (SCIDs) are a group of inherited disorders
responsible for severe dysfunctions of the immune system. These diseases are life …

Inborn errors of thymic stromal cell development and function lead to impaired T-cell
development resulting in a susceptibility to opportunistic infections and autoimmunity. In …

Introduction In a cancer-free environment in the adult, the skeleton continuously undergoes
remodeling. Bone-resorbing osteoclasts excavate erosion cavities, and bone-depositing …

Congenital athymia is an ultra-rare disease characterized by the absence of a functioning
thymus. It is associated with several genetic and syndromic disorders including FOXN1 …

FOXN1 is the master regulatory gene of thymic epithelium development. FOXN1 deficiency
leads to thymic aplasia, alopecia, and nail dystrophy, accounting for the nude/severe …

The thymus is the crucial tissue where thymocytes develop from hematopoietic precursors
that originate from the bone marrow and differentiate to generate a repertoire of mature T …

Atopic disorders, including atopic dermatitis, food and environmental allergies, and asthma,
are increasingly prevalent diseases. Atopic disorders are often associated with eosinophilia …

We report on 2 patients with compound heterozygous mutations in forkhead box N1
(FOXN1), a transcription factor essential for thymic epithelial cell (TEC) differentiation. TECs …

Combined Immunodeficiencies (CID) are rare congenital disorders characterized by
defective T-cell development that may be associated with B-and NK-cell deficiency. They are …

As the primary site for T cell development, the thymus is responsible for the production and
selection of a functional, yet self-tolerant T cell repertoire. This critically depends on thymic …