Introduction The normal bladder functions, storage and elimination of urine, are based on a
coordinated interplay of reciprocal contraction and relaxation of the bladder and the outflow …

From time to time we publish a full review of drugs that are available for the treatment of
common conditions. In this issue, the review is written by two of the leading authorities in the …

CONTEXT: Antimuscarinics are the drugs of choice for the treatment of detrusor overactivity
(DO) and overactive bladder (OAB) syndrome. However, the mechanisms for their beneficial …

Antimuscarinic agents are now widely used as the pharmacological therapy for overactive
bladder (OAB) because neuronal (parasympathetic nerve) and non-neuronal acetylcholine …

Antimuscarinic drugs are generally thought to exert their therapeutic action on detrusor
overactivity by reducing the ability of the detrusor muscle to contract. We review currently …

Lower urinary tract symptoms (LUTS) are commonly divided into storage, voiding, and
postmicturition symptoms, and may occur in both men and women. Male LUTS have …

Aims To discuss (1) mechanisms involved in the generation and control of myocyte
contractions and consequent afferent nerve activity and (2) these mechanisms as targets for …

There are several conditions associated with dysfunction of the lower urinary tract or which
result in a reduction in the ability to engage in satisfactory sexual function and result in …

Acetylcholine acting on muscarinic M3 receptors on the detrusor muscle is the principal
stimulus for inducing the contractile response for urinary bladder voiding. The urinary …

For many people a recurrent strong desire to void, sometimes with incontinence, diminishes
their quality of life. At present there are few insights into what underlies these problems. The …