Aging is the greatest risk factor for a multitude of diseases including cardiovascular disease,
neurodegeneration and cancer. Despite decades of research dedicated to understanding …

Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have
evolved as regulators of important signaling pathways. It is now well accepted that moderate …

The discoveries leading to our present understanding of the glutathione peroxidases (GPxs)
are recalled. The cytosolic GPx, now GPx1, was first described by Mills in 1957 and claimed …

Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …

Reactive oxygen species (ROS) are important signaling molecules in cancer. The level of
ROS will determine physiological effects. While high levels of ROS can cause damage to …

Increased reactive oxygen species (ROS) production has been detected in various cancers
and has been shown to have several roles, for example, they can activate pro-tumourigenic …

Reactive oxygen species (ROS), a group of highly reactive ions and molecules, are
increasingly being appreciated as powerful signaling molecules involved in the regulation of …

Life on Earth emerged in a hydrogen sulfide (H 2 S)-rich environment eons ago and with it
protein persulfidation mediated by H 2 S evolved as a signaling mechanism. Protein …

Superoxide ion (O2•–) is of great significance as a radical species implicated in diverse
chemical and biological systems. However, the chemistry knowledge of O2•–is rather …

Summary Hydrogen peroxide (H 2 O 2) is a key redox intermediate generated within cells.
Existing probes for H 2 O 2 have not solved the problem of detection of the ultra-low …