Monocyclic monoterpenes have been recognized as useful pharmacological ingredients
due to their ability to treat numerous diseases. Limonene and perillyl alcohol as well as their …

Chaperone-mediated autophagy (CMA) contributes to cellular quality control and the
cellular response to stress through the selective degradation of cytosolic proteins in …

Molecular hybridization is a recent strategy based on the covalent fusion of two or more
pharmacophores to create a single molecule with multiple mechanisms of action, which …

A series of fifteen novel dihydropyrimidinone hybrid compounds were synthesized in good
yields via a multicomponent reaction combined with the Huisgen reaction. The …

A facile route to perillyl alcohol (POH) differential glycosylation and the corresponding
synthesis of a set of 34 POH glycosides is reported. Subsequent in vitro studies revealed a …

Glioblastoma (GBM) is the most common and aggressive type of brain tumor in adults. The
triazene Temozolomide (TMZ), an alkylating drug, is the classical chemotherapeutic agent …

(R)-(+)-perillyl alcohol is a much valued supplemental compound with a wide range of
agricultural and pharmacological characteristics. The aim of this study was to improve (R) …

Some novel heteroretinoid-bisbenzylidine ketone hybrids have been synthesized and
evaluated for their in vitro antileishmanial activity against intramacrophagic amastigotes of …

Abstract (R)‐(+)‐perillyl alcohol is widely used in agricultural and anticarcinogenic fields.
Microbial production of (R)‐(+)‐perillyl alcohol was investigated in this study. We optimized …

Two series of amino-modified derivatives of (S)-perillyl alcohol were designed and
synthesized using (S)-perillaldehyde as the starting material. These derivatives showed …