Profilin is a ubiquitously expressed protein well known as a key regulator of actin
polymerisation. The actin cytoskeleton is involved in almost all cellular processes including …

This review covers aspects of cofilin and profilin regulations and their influence on actin
polymerisation responsible for cell motility and metastasis. The regulation of their activity by …

Huntingtin N-terminal fragments (Htt-NTFs) with expanded polyglutamine tracts form a range
of neurotoxic aggregates that are associated with Huntington's disease. Here, we show that …

Actin and microtubules play essential roles in aberrant cell processes that define and
converge in cancer including: signaling, morphology, motility, and division. Actin and …

Profilin is a major regulator of actin dynamics in multiple specific processes localized in
different cellular compartments. This specificity is not only meditated by its binding to actin …

Protein oligomerization in the cell has important implications for both health and disease,
and an understanding of the mechanisms by which proteins can self-associate is, therefore …

Oligomerization of allergens plays an important role in IgE-mediated reactions, as effective
crosslinking of IgE-FcεRI complexes on the cell membrane is dependent on the number of …

Background Profilins are actin-modulating proteins regulating many intracellular functions
based on their multiple and diverse ligand interactions. They have been implicated to play a …

Objective Dynamic regulation of actin cytoskeleton is at the heart of all actin-based cellular
events. In this study, we sought to identify novel post-translational modifications of Profilin-1 …

Hypoallergenic mutants with reduced IgE-binding capacity but which show a similar T-cell
response to the corresponding natural allergen are ideal tools for immunotherapy, for …