Chemistry of nitric oxide and related species

MN Hughes - Methods in enzymology, 2008 - Elsevier
Nitric oxide (NO) has essential roles in a remarkable number of diverse biological
processes. The reactivity of NO depends upon its physical properties, such as its small size …

[HTML][HTML] The emergence of nitroxyl (HNO) as a pharmacological agent

CH Switzer, W Flores-Santana, D Mancardi… - … et Biophysica Acta (BBA …, 2009 - Elsevier
Once a virtually unknown nitrogen oxide, nitroxyl (HNO) has emerged as a potential
pharmacological agent. Recent advances in the understanding of the chemistry of HNO has …

[HTML][HTML] Azanone (HNO): generation, stabilization and detection

CM Gallego, A Mazzeo, P Vargas, S Suárez… - Chemical …, 2021 - pubs.rsc.org
HNO (nitroxyl, azanone), joined the 'biologically relevant reactive nitrogen species' family in
the 2000s. Azanone is impossible to store due to its high reactivity and inherent low stability …

A recent history of nitroxyl chemistry, pharmacology and therapeutic potential

JM Fukuto - British journal of pharmacology, 2019 - Wiley Online Library
Due to the excitement surrounding the discovery of NO as an endogenously generated
signalling molecule, a number of other nitrogen oxides were also investigated as possible …

Nitric oxide is reduced to HNO by proton-coupled nucleophilic attack by ascorbate, tyrosine, and other alcohols. A new route to HNO in biological media?

SA Suarez, NI Neuman, M Muñoz… - Journal of the …, 2015 - ACS Publications
The role of NO in biology is well established. However, an increasing body of evidence
suggests that azanone (HNO), could also be involved in biological processes, some of …

Targeting NOS as a therapeutic approach for heart failure

L Tang, H Wang, MT Ziolo - Pharmacology & Therapeutics, 2014 - Elsevier
Nitric oxide is a key signaling molecule in the heart and is produced endogenously by three
isoforms of nitric oxide synthase, neuronal NOS (NOS1), endothelial NOS (NOS3), and …

The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems

W Flores-Santana, DJ Salmon, S Donzelli… - Antioxidants & redox …, 2011 - liebertpub.com
The importance of nitric oxide in mammalian physiology has been known for nearly 30
years. Similar attention for other nitrogen oxides such as nitroxyl (HNO) has been more …

Nitroxyl (azanone) trapping by metalloporphyrins

F Doctorovich, D Bikiel, J Pellegrino, SA Suárez… - Coordination Chemistry …, 2011 - Elsevier
The present review starts describing nitroxyl (azanone, 1HNO) biological relevance, in
relation with NO physiology, from a chemical reactivity perspective. After a description of …

Nitrous Oxide (N2O) production in axenic Chlorella vulgaris microalgae cultures: evidence, putative pathways, and potential environmental impacts

B Guieysse, M Plouviez, M Coilhac, L Cazali - Biogeosciences, 2013 - bg.copernicus.org
Using antibiotic assays and genomic analysis, this study demonstrates nitrous oxide (N 2 O)
is generated from axenic Chlorella vulgaris cultures. In batch assays, this production is …

When NO. Is not Enough: Chemical Systems, Advances and Challenges in the Development of NO. and HNO Donors for Old and Current Medical Issues

E Muniz Carvalho, EH Silva Sousa… - European Journal of …, 2021 - Wiley Online Library
Nitric oxide (NO.) has been widely studied as an active agent of many physiological and
pathological processes. Currently, NO. divides attention with its sibling molecule, nitroxyl …