Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation
The core pathology of coronavirus disease 2019 (COVID-19) is infection of airway cells by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that results in excessive …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that results in excessive …
The role of oxidative stress in diabetes mellitus-induced vascular endothelial dysfunction
Y An, B Xu, S Wan, X Ma, Y Long, Y Xu… - Cardiovascular …, 2023 - Springer
Diabetes mellitus is a metabolic disease characterized by long-term hyperglycaemia, which
leads to microangiopathy and macroangiopathy and ultimately increases the mortality of …
leads to microangiopathy and macroangiopathy and ultimately increases the mortality of …
Cardioprotective mechanism of SGLT2 inhibitor against myocardial infarction is through reduction of autosis
ABSTRACT Sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce cardiovascular
mortality in patients with diabetes mellitus but the protective mechanism remains elusive …
mortality in patients with diabetes mellitus but the protective mechanism remains elusive …
Inflammation, von Willebrand factor, and ADAMTS13
Increasing evidence indicates that inflammation can cause thrombosis by a von Willebrand
factor (VWF)-mediated mechanism that includes endothelial activation, secretion of VWF …
factor (VWF)-mediated mechanism that includes endothelial activation, secretion of VWF …
miR-24 targets the transmembrane glycoprotein neuropilin-1 in human brain microvascular endothelial cells
P Mone, J Gambardella, X Wang, SS Jankauskas… - Non-coding RNA, 2021 - mdpi.com
Neuropilin-1 is a transmembrane glycoprotein that has been implicated in several processes
including angiogenesis and immunity. Recent evidence has also shown that it is implied in …
including angiogenesis and immunity. Recent evidence has also shown that it is implied in …
Inducing mitophagy in diabetic platelets protects against severe oxidative stress
SH Lee, J Du, J Stitham, G Atteya, S Lee… - EMBO Molecular …, 2016 - embopress.org
Diabetes mellitus (DM) is a growing international concern. Considerable mortality and
morbidity associated with diabetes mellitus arise predominantly from thrombotic …
morbidity associated with diabetes mellitus arise predominantly from thrombotic …
Thrombosis and von Willebrand factor
M Shahidi - Thrombosis and Embolism: from Research to Clinical …, 2017 - Springer
One of the key players in both hemostasis and thrombosis is von Willebrand factor (vWF),
which demonstrates a duality between these two processes. Thrombus is structured by …
which demonstrates a duality between these two processes. Thrombus is structured by …
miR-23b-3p induces the cellular metabolic memory of high glucose in diabetic retinopathy through a SIRT1-dependent signalling pathway
Aims/hypothesis The mechanisms underlying the cellular metabolic memory induced by
high glucose remain unclear. Here, we sought to determine the effects of microRNAs …
high glucose remain unclear. Here, we sought to determine the effects of microRNAs …
Hyperglycaemia suppresses microRNA expression in platelets to increase P2RY12 and SELP levels in type 2 diabetes mellitus
Z Fejes, S Póliska, Z Czimmerer… - Thrombosis and …, 2017 - thieme-connect.com
Megakaryocyte (MK)-derived miRNAs have been detected in platelets. Here, we analysed
the expression of platelet and circulating miR-223, miR-26b, miR-126 and miR-140 that …
the expression of platelet and circulating miR-223, miR-26b, miR-126 and miR-140 that …
Knockout of beta-2 microglobulin enhances cardiac repair by modulating exosome imprinting and inhibiting stem cell-induced immune rejection
L Shao, Y Zhang, X Pan, B Liu, C Liang… - Cellular and Molecular …, 2020 - Springer
Background and aims Allogeneic human umbilical mesenchymal stem cells (alloUMSC) are
convenient cell source for stem cell-based therapy. However, immune rejection is a major …
convenient cell source for stem cell-based therapy. However, immune rejection is a major …