Mitogen-activated protein kinase (MAPK) pathways are conserved from yeast to man and
regulate a variety of cellular processes, including proliferation and differentiation. Recent …

Fungi exhibit an enormous variety of morphologies, including yeast colonies, hyphal
mycelia, and elaborate fruiting bodies. This diversity arises through a combination of polar …

Accurate detection of extracellular chemical gradients is essential for many cellular
behaviors. Gradient sensing is challenging for small cells, which can experience little …

Cells make accurate decisions in the face of molecular noise and environmental fluctuations
by relying not only on present pathway activity, but also on their memory of past signaling …

According to receptor theory, the effect of a ligand depends on the amount of agonist–
receptor complex. Therefore, changes in receptor abundance should have quantitative …

Animals are known to adjust their sexual behaviour depending on mate competition. Here
we report similar regulation for mating behaviour in a sexual unicellular eukaryote, the …

A common challenge in systems biology is quantifying the effects of unknown parameters
and estimating parameter values from data. For many systems, this task is computationally …

The ability to detect a chemical gradient is fundamental to many cellular processes. In
multicellular organisms gradient sensing plays an important role in many physiological …

Negative cooperativity is a phenomenon in which the binding of a first ligand or substrate
molecule decreases the rate of subsequent binding. This definition is not exclusive to ligand …

Cells detect changes in their environment and generate responses, often involving changes
in gene expression. In this paper we use information theory and a simple transcription model …