The suicide death toll is alarmingly high, outnumbering deaths from war and homicide
worldwide (1). Many factors contribute to suicide death, making it difficult to prevent because …

Drug addiction is a chronically relapsing disorder that has been characterized by (1)
compulsion to seek and take the drug,(2) loss of control in limiting intake, and (3) emergence …

There is converging evidence that high doses of hallucinogenic drugs can produce
significant alterations of self-experience, described as the dissolution of the sense of self …

Stress is most often associated with aversive states. It rapidly induces the release of
hormones and neuropeptides including dynorphin, which activates kappa opioid receptors …

The emerging novel therapeutic psilocybin produces psychedelic effects via engagement of
cerebral serotonergic targets by psilocin (active metabolite). The serotonin 2A receptor …

Dysregulation of the brain emotional systems that mediate arousal and stress is a key
component of the pathophysiology of drug addiction. Drug addiction is a chronically …

Written for practitioners in the field, this critically acclaimed bestseller provides authoritative
information focused on the investigation of drug-related deaths and practical approaches to …

The use of opioid medications on both an acute and chronic basis is ubiquitous in the United
States. As opioid receptors densely populate the gastrointestinal tract, symptoms and side …

The emergence of new psychoactive substances has earned a great deal of attention, and
several reports of acute poisoning and deaths have been issued involving, for instance …

In this paper, we present the development of the Altered States Database (ASDB), an open-
science project based on a systematic literature review. The ASDB contains psychometric …