Feasibility of using oral fluid for therapeutic drug monitoring of antiepileptic drugs
M Patrick, S Parmiter, SH Mahmoud - European Journal of Drug …, 2021 - Springer
Therapeutic drug monitoring (TDM) of antiepileptic drugs (AED) using blood is well
established but limited by its invasiveness, accessibility, cost, interpretation errors, and …
established but limited by its invasiveness, accessibility, cost, interpretation errors, and …
Salivary biomarkers of anti-epileptic drugs: a narrative review
Saliva is a biofluid that reflects general health and that can be collected in order to evaluate
and determine various pathologies and treatments. Biomarker analysis through saliva …
and determine various pathologies and treatments. Biomarker analysis through saliva …
Monitoring levetiracetam concentration in saliva during pregnancy is stable and feasible
W Li, X Yang, Q Chen, Z Wang… - CNS Neuroscience & …, 2024 - Wiley Online Library
Aims This multicenter prospective cohort study (registration no. ChiCTR2000032089) aimed
to investigate the relationship between saliva and plasma levetiracetam concentrations to …
to investigate the relationship between saliva and plasma levetiracetam concentrations to …
HPLC method for the determination of antiepileptic drugs in human saliva and its application in therapeutic drug monitoring
Epilepsy is one of the most prevalent neurological disorders, affecting approximately 1% of
the world population. Despite the availability of dozens of antiepileptic drugs (AEDs) in …
the world population. Despite the availability of dozens of antiepileptic drugs (AEDs) in …
Qualitative and Quantitative Mass Spectrometry in Salivary Metabolomics and Proteomics
P Grocholska, M Kowalska, R Bąchor - Metabolites, 2023 - mdpi.com
The metabolomics and proteomics analysis of saliva, an excellent biofluid that is a rich
source of biological compounds, allows for the safe and frequent screening of drugs, their …
source of biological compounds, allows for the safe and frequent screening of drugs, their …
HPLC–based methods for the determination of levetiracetam in biological and pharmaceutical samples
Levetiracetam is one of the new generation anti–epileptic agents (also known as
anticonvulsants or antiseizure drugs). Following its approval for marketing in 2000 …
anticonvulsants or antiseizure drugs). Following its approval for marketing in 2000 …
Quantification of levetiracetam in plasma and urine and its application to a pharmacokinetic study of traumatic brain injury patients
Background: Levetiracetam is an antiepileptic drug used to prevent or treat seizure in
patients with severe traumatic brain injury. This study aimed to develop and validate …
patients with severe traumatic brain injury. This study aimed to develop and validate …
Highly sensitive UHPLC–DAD method for simultaneous determination of two synergistically acting antiepileptic drugs; levetiracetam and lacosamide: Application to …
A simple and highly sensitive ultra‐high‐performance liquid chromatographic–diode array
(UHPLC‐DAD) detection method was developed and validated for the simultaneous …
(UHPLC‐DAD) detection method was developed and validated for the simultaneous …
Quantitation of levetiracetam concentrations in plasma and saliva samples by ultra‐performance liquid chromatography–tandem mass spectrometry: Application to …
M Zhang, Y Jin, W Li, C He, X Di, Y Duan… - Biomedical …, 2024 - Wiley Online Library
Although levetiracetam (LEV) has favorable linear pharmacokinetic properties, therapeutic
drug monitoring (TDM) is necessary for pregnant women with epilepsy. This study aims to …
drug monitoring (TDM) is necessary for pregnant women with epilepsy. This study aims to …
[PDF][PDF] Salivary Biomarkers of Anti-Epileptic Drugs: A Narrative Review. Diagnostics 2023, 13, 1962
Saliva is a biofluid that reflects general health and that can be collected in order to evaluate
and determine various pathologies and treatments. Biomarker analysis through saliva …
and determine various pathologies and treatments. Biomarker analysis through saliva …