Signaling pathways allow cells to detect and respond to a wide variety of chemical (eg Ca2+
or chemokine proteins) and physical stimuli (eg, sheer stress, light). Together, these …

Since their discovery a little more than a decade ago, the docking proteins of the Gab/DOS
family have emerged as important signalling elements in metazoans. Gab/DOS proteins …

Protein–peptide interactions play a crucial role in many cellular and biological functions,
which justify the increasing interest in the development of peptide-based drugs. However …

There are more ways to synthesize a 100-amino acid (aa) protein (20100) than there are
atoms in the universe. Only a very small fraction of such a vast sequence space can ever be …

SH3 domains are protein modules that mediate protein-protein interactions in many
eukaryotic signal transduction pathways. The majority of SH3 domains studied thus far act …

Background Sorting ubiquitinated epidermal growth factor receptor (EGFR) to the
intralumenal vesicles of the multivesicular body requires the coordinated action of several …

Adaptor or scaffolding proteins mediate protein–protein interactions that drive the formation
of protein complexes. Grb2-associated binding protein 2 (GAB2) scaffolding protein is an …

Thymocyte-expressed molecule involved in selection (THEMIS) is a recently identified
regulator of thymocyte positive selection. THEMIS's mechanism of action is unknown, and …

The assembly of complexes following the detection of extracellular signals is often controlled
by signaling proteins comprising multiple peptide binding modules. The SRC homology …

Grb2 is an adaptor protein that recruits Ras-specific guanine nucleotide exchange factor,
Son of Sevenless 1 (SOS1), to the plasma membrane. SOS1 exchanges GDP by GTP …