Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a
high morbidity additionally, CRC patients may develop liver metastasis, which is the major …

Resistance to cancer therapy is a major barrier to cancer management. Conventional views
have proposed that acquisition of resistance may result from genetic mutations. However …

Tumor metastasis is a hallmark of cancer. The communication between cancer-derived
exosomes and stroma plays an irreplaceable role in facilitating pre-metastatic niche …

Several cancer interventions induce DNA damage and promote senescence in cancer and
nonmalignant cells. Senescent cells secrete a collection of proinflammatory factors …

Despite remarkable clinical efficacy of immune checkpoint blockade (ICB) in cancer
treatment, ICB benefits for triple-negative breast cancer (TNBC) remain limited. Through …

The components of the tumor microenvironment (TME) in solid tumors, especially
chemokines, are currently attracting much attention from scientists. C‐X‐C motif chemokine …

Vessel co-option has been demonstrated to mediate colorectal cancer liver metastasis
(CRCLM) resistance to antiangiogenic therapy. The current mechanisms underlying vessel …

Cancer metastasis is responsible for the vast majority of cancer‐related deaths worldwide. In
contrast to numerous discoveries that reveal the detailed mechanisms leading to the …

Neutrophils are significant compositions of solid tumors and exert distinct functions in
different types of tumors. However, the precise role of neutrophils in the progression of …

Cancer‐associated fibroblasts (CAFs) play a key role in orchestrating the tumor malignant
biological properties within tumor microenvironment and evidences demonstrate that CAFs …